Role of the inhibitor of serine peptidase 2 (ISP2) of Trypanosoma brucei rhodesiense in parasite virulence and modulation of the inflammatory responses of the host
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0009526
Abstract: Trypanosoma brucei rhodesiense is one of the causative agents of Human African Trypanosomiasis (HAT), known as sleeping sickness. The parasite invades the central nervous system and causes severe encephalitis that is fatal if left untreated.… read more here.
Keywords: brucei rhodesiense; role; isp2; trypanosoma brucei ... See more keywords
Dipeptide Nitrile CD34 with Curcumin: A New Improved Combination Strategy to Synergistically Inhibit Rhodesain of Trypanosoma brucei rhodesiense
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24108477
Abstract: Rhodesain is the main cysteine protease of Trypanosoma brucei rhodesiense, the parasite causing the acute lethal form of Human African Trypanosomiasis. Starting from the dipeptide nitrile CD24, the further introduction of a fluorine atom in… read more here.
Keywords: brucei rhodesiense; trypanosoma brucei; combination; dipeptide nitrile ... See more keywords
The Alkaloid-Enriched Fraction of Pachysandra terminalis (Buxaceae) Shows Prominent Activity against Trypanosoma brucei rhodesiense
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26030591
Abstract: In the course of our studies on antiprotozoal natural products and following our recent discovery that certain aminosteroids and aminocycloartanoid compounds from Holarrhena africana A. DC. (Apocynaceae) and Buxus sempervirens L. (Buxaceae), respectively, are strong… read more here.
Keywords: brucei rhodesiense; pachysandra terminalis; trypanosoma brucei; activity trypanosoma ... See more keywords
Haemoparasitic Infections in Cattle from a Trypanosoma brucei Rhodesiense Sleeping Sickness Endemic District of Eastern Uganda
Sign Up to like & getrecommendations! Published in 2020 at "Tropical Medicine and Infectious Disease"
DOI: 10.3390/tropicalmed5010024
Abstract: We carried out a baseline survey of cattle in Kaberamaido district, in the context of controlling the domestic animal reservoir of Trypanosoma brucei rhodesiense human African trypanosomiasis (rHAT) towards elimination. Cattle blood was subjected to… read more here.
Keywords: eastern uganda; brucei rhodesiense; district; trypanosoma brucei ... See more keywords