Brucine promotes apoptosis in cervical cancer cells (ME‐180) via suppression of inflammation and cell proliferation by regulating PI3K/AKT/mTOR signaling pathway
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DOI: 10.1002/tox.23304
Abstract: Brucine are the main constituents of Strychnos nux‐vomica. Earlier reports have determined brucine shows anti‐inflammatory, analgesic and excellent anti‐tumor drug. Even though its anticervical cancer cells remains not clearly evaluated. So that, we hypothesized the… read more here.
Keywords: cell proliferation; cell; brucine; cervical cancer ... See more keywords
Licorice Extracts Attenuate Nephrotoxicity Induced by Brucine Through Suppression of Mitochondria Apoptotic Pathway and STAT3 Activation
Sign Up to like & getrecommendations! Published in 2019 at "Current Medical Science"
DOI: 10.1007/s11596-019-2126-z
Abstract: Licorice, one of the most widely used medicinal herbs in East Asia, has effects such as anti-inflammation, antioxidant, and detoxifying. This study aimed to evaluate the protective effect of licorice on brucine-induced nephrotoxicity. Sprague Dawley… read more here.
Keywords: stat3 activation; brucine; licorice; nephrotoxicity ... See more keywords
Removal of hERG potassium channel affinity through introduction of an oxygen atom: Molecular insights from structure‐activity relationships of strychnine and its analogs
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DOI: 10.1016/j.taap.2018.09.042
Abstract: &NA; Nux vomica has been effectively used in Traditional Chinese Medicine. The processing of Nux vomica is necessary to reduce toxicity before it can be used in clinical practice. However, the mechanism for processing detoxification… read more here.
Keywords: channel; strychnine brucine; brucine; herg channels ... See more keywords
Brucine Suppresses Vasculogenic Mimicry in Human Triple-Negative Breast Cancer Cell Line MDA-MB-231
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DOI: 10.1155/2019/6543230
Abstract: Vasculogenic mimicry (VM) with the pattern of endothelial independent tubular structure formation lined by aggressive tumor cells mimics regular tumor blood vessels to ensure robust blood supply and correlates with the proliferation, invasion, metastasis, and… read more here.
Keywords: vasculogenic mimicry; brucine; cancer; cell ... See more keywords