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   Articles with "brugia malayi" as a keyword



Monitoring thermal and chemical unfolding of Brugia malayi calreticulin using fluorescence and Circular Dichroism spectroscopy.

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recommendations! Published in 2017 at "International journal of biological macromolecules"

DOI: 10.1016/j.ijbiomac.2017.04.053

Abstract: Calreticulin of Brugia malayi (BmCRT) play very important role in host-parasite interaction. In previous study it was found that BmCRT is responsible for prevention of host classical complement pathway activation via its interaction with first… read more here.

Keywords: bmcrt; brugia malayi; calreticulin; spectroscopy ... See more keywords
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Therapeutic trial of doxycyclin plus ivermectin for the treatment of Brugia malayi naturally infected cats.

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recommendations! Published in 2017 at "Veterinary parasitology"

DOI: 10.1016/j.vetpar.2017.08.009

Abstract: Lymphatic filariasis (LF) is one of the neglected tropical diseases which causes permanent and long term disability worldwide. LF is caused by filarial nematode parasites, i.e. Wuchereria bancrofti, Brugia malayi, and B. timori. All available… read more here.

Keywords: infected cats; treatment; malayi naturally; naturally infected ... See more keywords
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De novo Assembly of the Brugia malayi Genome Using Long Reads from a Single MinION Flowcell

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recommendations! Published in 2019 at "Scientific Reports"

DOI: 10.1038/s41598-019-55908-y

Abstract: Filarial nematode infections cause a substantial global disease burden. Genomic studies of filarial worms can improve our understanding of their biology and epidemiology. However, genomic information from field isolates is limited and available reference genomes… read more here.

Keywords: minion flowcell; brugia malayi; minion; single minion ... See more keywords
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Nodulisporic acid produces direct activation and positive allosteric modulation of AVR-14B, a glutamate-gated chloride channel from adult Brugia malayi

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2111932119

Abstract: Significance Filarial nematodes affect millions of people globally and constitute a serious public health issue in tropical and subtropical regions. Ivermectin (IVM) is used in combination with other chemotherapeutic agents for treatment and control of… read more here.

Keywords: avr 14b; brugia malayi; glutamate gated; nodulisporic acid ... See more keywords
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Localization and RNA Interference-Driven Inhibition of a Brugia malayi-Encoded Interleukin-5 Receptor Binding Protein

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recommendations! Published in 2022 at "Infection and Immunity"

DOI: 10.1128/iai.00317-21

Abstract: A molecule we termed Brugia malayi IL-5 receptor (IL-5R) binding protein (BmIL5Rbp; also known as Bm8757) was identified from B. malayi filarial worms and found to inhibit human interleukin-5 (IL-5) binding to its human receptor… read more here.

Keywords: malayi; bmil5rbp; microscopy; brugia malayi ... See more keywords
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Molecular Characterization of a Reemergent Brugia malayi Parasite in Sri Lanka, Suggestive of a Novel Strain

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recommendations! Published in 2021 at "BioMed Research International"

DOI: 10.1155/2021/9926101

Abstract: Sri Lanka achieved elimination status for lymphatic filariasis in 2016; still, the disease remains a potential public health issue. The present study is aimed at identifying a subperiodic Brugia sp. parasite which has reemerged in… read more here.

Keywords: brugia malayi; novel strain; malayi; sri lanka ... See more keywords
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Human Leukocytes Kill Brugia malayi Microfilariae Independently of DNA-Based Extracellular Trap Release

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recommendations! Published in 2017 at "PLoS Neglected Tropical Diseases"

DOI: 10.1371/journal.pntd.0005279

Abstract: Background Wuchereria bancrofti, Brugia malayi and Brugia timori infect over 100 million people worldwide and are the causative agents of lymphatic filariasis. Some parasite carriers are amicrofilaremic whilst others facilitate mosquito-based disease transmission through blood-circulating… read more here.

Keywords: malayi microfilariae; pmn attachment; kill malayi; brugia malayi ... See more keywords
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Development of a toolkit for piggyBac-mediated integrative transfection of the human filarial parasite Brugia malayi

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recommendations! Published in 2018 at "PLoS Neglected Tropical Diseases"

DOI: 10.1371/journal.pntd.0006509

Abstract: Background The human filarial parasites cause diseases that are among the most important causes of morbidity in the developing world. The elimination programs targeting these infections rely on a limited number of drugs, making the… read more here.

Keywords: brugia malayi; human filarial; integrative transfection; filarial parasite ... See more keywords
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Prediction pipeline for discovery of regulatory motifs associated with Brugia malayi molting

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recommendations! Published in 2020 at "PLoS Neglected Tropical Diseases"

DOI: 10.1371/journal.pntd.0008275

Abstract: Filarial nematodes can cause debilitating diseases in humans. They have complicated life cycles involving an insect vector and mammalian hosts, and they go through a number of developmental molts. While whole genome sequences of parasitic… read more here.

Keywords: brugia malayi; discovery; prediction pipeline; pipeline ... See more keywords
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Structural features and development of an assay platform of the parasite target deoxyhypusine synthase of Brugia malayi and Leishmania major

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recommendations! Published in 2020 at "PLoS Neglected Tropical Diseases"

DOI: 10.1371/journal.pntd.0008762

Abstract: Deoxyhypusine synthase (DHS) catalyzes the first step of the post-translational modification of eukaryotic translation factor 5A (eIF5A), which is the only known protein containing the amino acid hypusine. Both proteins are essential for eukaryotic cell… read more here.

Keywords: leishmania major; malayi leishmania; deoxyhypusine synthase; target ... See more keywords
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Reconstitution of an N-AChR from Brugia malayi, an evolved change in acetylcholine receptor accessory protein requirements in filarial parasites

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recommendations! Published in 2022 at "PLOS Pathogens"

DOI: 10.1371/journal.ppat.1010962

Abstract: Neurotransmission is an important target for anthelmintic drugs, where receptor characteristics and response can be examined through reconstitution ex vivo in Xenopus laevis oocytes. The homomeric ACR-16 nicotine sensitive acetylcholine receptors (N-AChRs) of several helminth… read more here.

Keywords: malayi; accessory; brugia malayi; acetylcholine ... See more keywords