Total synthesis of bryostatin 3
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DOI: 10.1126/science.abb7271
Abstract: Stitching alkynes into bryostatin 3 The bryostatin family of marine natural products has been explored for a wide variety of pharmaceutical applications but remains challenging to source. The general structure comprises a macrocycle that contains… read more here.
Keywords: total synthesis; synthesis bryostatin; synthesis; bryostatin ... See more keywords
Preclinical and clinical studies on bryostatins, a class of marine-derived protein kinase C modulators: A mini-review.
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DOI: 10.2174/1568026620666200325110444
Abstract: Bryostatins are complex macrolactones isolated from marine organism Bryozoan Bugula neritina. They are potent modulators of protein kinase C isozymes (PKCα: ki = 1.3-188 nM), and are one of the most extensively investigated marine natural… read more here.
Keywords: clinical studies; alzheimer disease; protein kinase; studies bryostatins ... See more keywords
Bryostatin Placebo-Controlled Trials Indicate Cognitive Restoration Above Baseline for Advanced Alzheimer’s Disease in the Absence of Memantine
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Alzheimer's Disease"
DOI: 10.3233/jad-215545
Abstract: Background: In pre-clinical studies of Alzheimer’s disease (AD) transgenic mice, bryostatin restored synaptic connections, prevented neuronal death, reduced amyloid plaques, and reduced neurofibrillary tangles. Objective: Within pre-specified cohorts of advanced AD patients in two double-blind… read more here.
Keywords: baseline; alzheimer disease; placebo; sib ... See more keywords