Total synthesis of bryostatin 3
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DOI: 10.1126/science.abb7271
Abstract: Stitching alkynes into bryostatin 3 The bryostatin family of marine natural products has been explored for a wide variety of pharmaceutical applications but remains challenging to source. The general structure comprises a macrocycle that contains… read more here.
Keywords: total synthesis; synthesis bryostatin; synthesis; bryostatin ... See more keywords
Bryostatin-1 protects against amyloid- beta (Aβ) oligomer-induced neurotoxicity by activating autophagy
Sign Up to like & getrecommendations! Published in 2024 at "Brazilian Journal of Pharmaceutical Sciences"
DOI: 10.1590/s2175-97902024e23239
Abstract: The expression of PKCε, a member of the protein kinase C family, has been found to be decreased in the frontal cortex of patients with Alzheimer’s disease (AD). Bryostatin-1 is a PKCε activator and has… read more here.
Keywords: bryo; bryostatin; induced neurotoxicity; oligomer induced ... See more keywords
Preclinical and clinical studies on bryostatins, a class of marine-derived protein kinase C modulators: A mini-review.
Sign Up to like & getrecommendations! Published in 2020 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026620666200325110444
Abstract: Bryostatins are complex macrolactones isolated from marine organism Bryozoan Bugula neritina. They are potent modulators of protein kinase C isozymes (PKCα: ki = 1.3-188 nM), and are one of the most extensively investigated marine natural… read more here.
Keywords: clinical studies; alzheimer disease; protein kinase; studies bryostatins ... See more keywords
Bryostatin Placebo-Controlled Trials Indicate Cognitive Restoration Above Baseline for Advanced Alzheimer’s Disease in the Absence of Memantine
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DOI: 10.3233/jad-215545
Abstract: Background: In pre-clinical studies of Alzheimer’s disease (AD) transgenic mice, bryostatin restored synaptic connections, prevented neuronal death, reduced amyloid plaques, and reduced neurofibrillary tangles. Objective: Within pre-specified cohorts of advanced AD patients in two double-blind… read more here.
Keywords: baseline; alzheimer disease; placebo; sib ... See more keywords
Bryostatin-1 enhances the proliferation and functionality of exhausted CD8+ T cells by upregulating MAP Kinase 11
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DOI: 10.3389/fimmu.2024.1509874
Abstract: Introduction Bryostatin-1, a potent agonist of the protein kinase C, has been studied for HIV and cancer therapies. In HIV research, it has shown anti-HIV effects during acute infection and reactivation of latent HIV in… read more here.
Keywords: bryostatin; cd8 cells; hiv specific; exhausted cd8 ... See more keywords
Anticancer Activity of the Marine-Derived Compound Bryostatin 1: Preclinical and Clinical Evaluation
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DOI: 10.3390/ijms26167765
Abstract: Bryostatin 1, a natural macrolide isolated from Bugula neritina, is a potent modulator of protein kinase C (PKC) isoforms with promising anticancer properties. In numerous in vitro studies, bryostatin 1 has been shown to inhibit… read more here.
Keywords: bryostatin; marine derived; anticancer; anticancer activity ... See more keywords