Analysis of surgical interruption of the enterohepatic circulation as a treatment for pediatric cholestasis
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.29019
Abstract: To evaluate the efficacy of nontransplant surgery for pediatric cholestasis, 58 clinically diagnosed children, including 20 with Alagille syndrome (ALGS), 16 with familial intrahepatic cholestasis‐1 (FIC1), 18 with bile salt export pump (BSEP) disease, and… read more here.
Keywords: fic1; pediatric cholestasis; preoperatively months; bsep ... See more keywords
Loss of bile salt export pump aggravates lipopolysaccharide-induced liver injury in mice due to impaired hepatic endotoxin clearance.
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.32289
Abstract: BACKGROUND AND AIMS LPS clearance is delayed in cholestatic liver diseases. While compromised clearance by Kupffer cells (KCs) is involved, the role of LPS uptake into hepatocytes and canalicular excretion remains unclear. APPROACH AND RESULTS… read more here.
Keywords: mice; bsep; clearance; liver injury ... See more keywords
Vesicle- and Hepatocyte-Based Assays for Identification of Drug Candidates Inhibiting BSEP Function.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9420-5_4
Abstract: Transporters play a crucial role in the uptake of endo- and exogenous molecules in hepatocytes and efflux into the bile. The bile salt export pump (BSEP; ABCB11) is of major importance for efflux of bile… read more here.
Keywords: bile salt; hepatocyte based; based assays; vesicle hepatocyte ... See more keywords
Anticholestatic mechanisms of ursodeoxycholic acid in lipopolysaccharide-induced cholestasis.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.06.009
Abstract: Lipopolysaccharide (LPS) from Gram (-) bacteria induces inflammatory cholestasis by impairing the expression/localization of transporters involved in bile formation (e.g., Bsep, Mrp2). Therapeutic options for this disease are lacking. Ursodeoxycholic acid (UDCA) is the first… read more here.
Keywords: plasma; ursodeoxycholic acid; expression; bsep ... See more keywords
Mechanistic insights into geniposide regulation of bile salt export pump (BSEP) expression
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DOI: 10.1039/c8ra06345a
Abstract: Geniposide (GE) is a major component isolated from Gardenia jasminoides Ellis, which has been used to treat cholestasis liver diseases. Our previous study has shown that GE could notably increase mRNA and protein expressions of… read more here.
Keywords: fxr; bsep expression; bsep promoter; expression ... See more keywords
Histological demonstration of BSEP/ABCB11 inhibition in transient neonatal cholestasis: a case report
Sign Up to like & getrecommendations! Published in 2020 at "BMC Pediatrics"
DOI: 10.1186/s12887-020-02201-x
Abstract: Background Idiopathic or transient neonatal cholestasis (TNC) represents a group of cholestatic disorders with unidentified origin and remains a diagnosis of exclusion. Dysfunction of hepatobiliary transporters mediating excretion of biliary constituents from hepatocytes may play… read more here.
Keywords: bsep abcb11; neonatal cholestasis; transient neonatal; report ... See more keywords
The Role of the Sodium-taurocholate Co-transporting Polypeptide (NTCP) and Bile Salt Export Pump (BSEP) in Related Liver Disease.
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DOI: 10.2174/1389200220666190426152830
Abstract: BACKGROUND Sodium Taurocholate Co-transporting Polypeptide (NTCP) and Bile Salt Export Pump (BSEP) play significant roles as membrane transporters because of their presence in the enterohepatic circulation of bile salts. They have emerged as promising drug… read more here.
Keywords: sodium taurocholate; transporting polypeptide; taurocholate transporting; bsep ... See more keywords