Discovery and resistance mechanism of a selective CDK12 degrader
Sign Up to like & getrecommendations! Published in 2021 at "Nature Chemical Biology"
DOI: 10.1038/s41589-021-00765-y
Abstract: Cyclin-dependent kinase 12 (CDK12) is an emerging therapeutic target due to its role in regulating transcription of DNA-damage response (DDR) genes. However, development of selective small molecules targeting CDK12 has been challenging due to the… read more here.
Keywords: bsj 116; discovery resistance; mechanism; degrader ... See more keywords