Discovery of Covalent MKK4/7 Dual Inhibitor.
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DOI: 10.1016/j.chembiol.2020.08.014
Abstract: MKK4/7 are kinases that phosphorylate JNKs and regulate the MAPK signaling pathway. Their overexpression has been associated with tumorigenesis and aggressiveness in cancers such as breast, prostate, non-small cell lung, and pediatric leukemia, making them… read more here.
Keywords: inhibitor; bsj 122; discovery covalent; mkk4 ... See more keywords