The viral restriction factor tetherin/BST2 tethers cytokinetic midbody remnants to the cell surface
Sign Up to like & getrecommendations! Published in 2021 at "Current Biology"
DOI: 10.1016/j.cub.2021.02.039
Abstract: The midbody at the center of the intercellular bridge connecting dividing cells recruits the machinery essential for the final steps of cytokinesis.1-5 Successive abscission on both sides of the midbody generates a free midbody remnant… read more here.
Keywords: cell surface; bst2; midbody; midbody remnants ... See more keywords
BST2 impairs Schwann cell function to accelerate age-related hearing loss and serves as a novel serum biomarker.
Sign Up to like & getrecommendations! Published in 2025 at "Acta oto-laryngologica"
DOI: 10.1080/00016489.2025.2591707
Abstract: BACKGROUND Age-related hearing loss (ARHL) represents the most prevalent sensory disorder among the elderly, significantly impairing daily functioning and increasing the risk of psychiatric conditions. Although Schwann cells (SCs) are critical for maintaining auditory nerve… read more here.
Keywords: arhl; function; serum biomarker; age related ... See more keywords
Bone marrow stromal cell antigen 2(BST2) suppresses the migration and invasion of trophoblasts in preeclampsia by downregulating matrix metallopeptidase 2(MMP2)
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2074712
Abstract: ABSTRACT Preeclampsia is a grievous pregnancy-related complication with an incidence of approximately 5∼7% in pregnant women. Placental abnormalities and decreased placental perfusion associated with impaired trophoblast invasion are early pathological findings of preeclampsia. BST2 is… read more here.
Keywords: migration invasion; bst2; mmp2; expression ... See more keywords
SPARCL1 targeting BST2 mediates meniscal inflammation and catabolic dysfunction by activating the NF-κB/P65 pathway.
Sign Up to like & getrecommendations! Published in 2025 at "Rheumatology"
DOI: 10.1093/rheumatology/keaf345
Abstract: OBJECTIVES Meniscus injury is one of the most common musculoskeletal injuries, and its pathogenesis is associated with age, mechanical stress, and inflammatory injury. However, the mechanism of meniscal degeneration remains unclear, and this study aimed… read more here.
Keywords: sparcl1; degeneration; meniscus; p65 pathway ... See more keywords
BST2 Drives Epithelial Ovarian Cancer Progression via Macrophage M2 Polarization, Neural Remodeling, and Immunosuppressive Microenvironment Formation
Sign Up to like & getrecommendations! Published in 2025 at "Human Mutation"
DOI: 10.1155/humu/8719836
Abstract: Background Epithelial ovarian cancer (EOC) ranks as the most lethal of gynecological cancers. Despite advances in therapeutic interventions that have marginally extended survival rates, the early detection and management of EOC pose significant hurdles. Consequently,… read more here.
Keywords: macrophage polarization; macrophage; ovarian cancer; expression ... See more keywords
Abstract 4134531: BST2 induces vascular smooth muscle cell plasticity and phenotype switching during cancer progression
Sign Up to like & getrecommendations! Published in 2024 at "Circulation"
DOI: 10.1161/circ.150.suppl_1.4134531
Abstract: Rationale: Smooth muscle cell (SMC) plasticity and phenotypic switching play prominent roles in the pathogenesis of multiple diseases like atherosclerosis and pulmonary hypertension, but their role in tumorigenesis is unknown. Objective: To investigate SMC diversity… read more here.
Keywords: cancer; plasticity; tumor; cell ... See more keywords
Hepatitis E Virus (HEV) egress: Role of BST2 (Tetherin) and interferon induced long non- coding RNA (lncRNA) BISPR
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0187334
Abstract: Background The biology of Hepatitis E Virus (HEV), a common cause of epidemic and sporadic hepatitis, is still being explored. HEV exits liver through bile, a process which is essential for its natural transmission by… read more here.
Keywords: bst2; bispr; hev; hepatitis virus ... See more keywords
Promotion of BST2 expression by the transcription factor IRF6 affects the progression of endometriosis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1115504
Abstract: Background Endometriosis (EM) is a benign, multifactorial, immune-mediated inflammatory disease that is characterized by persistent activation of the NF‐κB signaling pathway and some features of malignancies, such as proliferation and lymphangiogenesis. To date, the pathogenesis… read more here.
Keywords: endometriosis; bst2 expression; bst2; factor irf6 ... See more keywords
BST2 regulated by the transcription factor STAT1 can promote metastasis, invasion and proliferation of oral squamous cell carcinoma via the AKT/ERK1/2 signaling pathway
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Oncology"
DOI: 10.3892/ijo.2023.5502
Abstract: Oral squamous cell carcinoma (OSCC) is one of the main types of head and neck squamous cell carcinoma. Although progress has been made in treating OSCC, it remains a threat to human health, and novel… read more here.
Keywords: cell carcinoma; oscc; signaling pathway; squamous cell ... See more keywords