Cu(ii)-TACN complexes selectively induce antitumor activity in HepG-2 cells via DNA damage and mitochondrial-ROS-mediated apoptosis.
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DOI: 10.1039/c9dt03641e
Abstract: A new 1,4,7-triazacyclononane derivative, 4-benzyloxy-benzyl-1,4,7-triazacyclononane (btacn), and three associated cyclen complexes, Cu(btacn)Cl2, Zn(btacn)Cl2 and [Cu(btacn)2]ยท(ClO4)2, were prepared to serve as DNA synthesis interferents. The compounds were characterized using IR, 1H and 13C NMR, ESI-MS, elemental… read more here.
Keywords: hepg; btacn cl2; damage; dna ... See more keywords