Oral anserine supplementation does not attenuate type-2 diabetes or diabetic nephropathy in BTBR ob/ob mice.
Sign Up to like & getrecommendations! Published in 2021 at "Amino acids"
DOI: 10.1007/s00726-021-03033-4
Abstract: Carnosine, a naturally occurring dipeptide present in an omnivorous diet, has been shown to ameliorate the development of metabolic syndrome, type-2 diabetes (T2D) and early- and advanced-stage diabetic nephropathy in different rodent models. Anserine, its… read more here.
Keywords: supplementation; anserine; diabetic nephropathy; mice ... See more keywords
Postweaning social isolation and autism-like phenotype: A biochemical and behavioral comparative analysis
Sign Up to like & getrecommendations! Published in 2022 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2022.113891
Abstract: Adolescence is a critical period for brain development. In most mammalian species, disturbances experienced during adolescence constitute a risk factor for several neuropsychiatric disorders. In this study, we compared the biochemical and behavioral profile induced… read more here.
Keywords: mice; social isolation; biochemical behavioral; btbr mice ... See more keywords
The Stat3 inhibitor, S3I-201, downregulates lymphocyte activation markers, chemokine receptors, and inflammatory cytokines in the BTBR T+ Itpr3tf/J mouse model of autism
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2019.07.006
Abstract: Autism is a complex neurodevelopmental disorder with a high incidence rate. It is characterized by deficits in communication, a lack of social skills, cognitive inflexibility, and stereotypical behaviors. Autism has been gradually increasing in children… read more here.
Keywords: autism; stat3 inhibitor; btbr mice; btbr itpr3tf ... See more keywords
Selenium inhibits ferroptosis and ameliorates autistic-like behaviors of BTBR mice by regulating the Nrf2/GPx4 pathway
Sign Up to like & getrecommendations! Published in 2022 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2022.02.018
Abstract: BACKGROUND Autism spectrum disorder (ASD) is a group of extensive neurodevelopmental disorders for which few efficacious drugs are available. Sodium selenite (Se), the most common inorganic form of selenium given to humans and animals, has… read more here.
Keywords: ferroptosis; nrf2 gpx4; btbr mice; gpx4 pathway ... See more keywords
The potent immunomodulatory compound VGX-1027 regulates inflammatory mediators in CD4+ T cells, which are concomitant with the prevention of neuroimmune dysregulation in BTBR T+ Itpr3tf/J mice.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.116930
Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by symptoms that include social communication impairments, interaction deficits, and repetitive and stereotyped behaviors. Recent studies have suggested that imbalanced cytokine levels are associated with impaired… read more here.
Keywords: mice; cd4 cells; btbr mice; vgx 1027 ... See more keywords
Cross-site Reproducibility of Social Deficits in Group-housed BTBR Mice Using Automated Longitudinal Behavioural Monitoring
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2020.04.045
Abstract: Social withdrawal is associated with a variety of neuropsychiatric disorders, including neurodevelopmental disorders. Rodent studies provide the opportunity to study neurobiological mechanisms underlying social withdrawal, however, homologous paradigms to increase translatability of social behaviour between… read more here.
Keywords: cross site; reproducibility; mice; mice using ... See more keywords
Assessment of DNA repair efficiency in the inbred BTBR T + tf/J autism spectrum disorder mouse model exposed to gamma rays and treated with JNJ7777120
Sign Up to like & getrecommendations! Published in 2019 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2019.04.003
Abstract: Information regarding DNA repair in autism is limited to a few studies, which have reported inconsistent results. Therefore, we designed a study to determine whether DNA repair efficiency is altered in autism and to investigate… read more here.
Keywords: dna repair; dna; btbr mice; mice ... See more keywords
Circadian Responses to Light in the BTBR Mouse
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biological Rhythms"
DOI: 10.1177/07487304221102279
Abstract: Animals with altered freerunning periods are valuable in understanding properties of the circadian clock. Understanding the relationship between endogenous clock properties, entrainment, and influence of light in terms of parametric and non-parametric models can help… read more here.
Keywords: phase; circadian responses; btbr mice; btbr ... See more keywords
Lithium reduces blood glucose levels, but aggravates albuminuria in BTBR-ob/ob mice
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0189485
Abstract: Glycogen synthase kinase 3 (GSK3) plays an important role in the development of diabetes mellitus and renal injury. GSK3 inhibition increases glucose uptake in insulin-insensitive muscle and adipose tissue, while it reduces albuminuria and glomerulosclerosis… read more here.
Keywords: glucose levels; lithium; btbr mice; blood glucose ... See more keywords
Postweaning social isolation and autism-like phenotype: A biochemical and behavioral comparative analysis
Sign Up to like & getrecommendations! Published in 2022 at "Behavioural Brain Research"
DOI: 10.2139/ssrn.3979567
Abstract: Adolescence is a critical period for brain development. In most mammalian species, disturbances experienced during adolescence constitute a risk factor for several neuropsychiatric disorders. In this study, we compared the biochemical and behavioral profile induced… read more here.
Keywords: autism; biochemical behavioral; btbr mice; postweaning social ... See more keywords
Altered Expression and in vivo Activity of mGlu5 variant a Receptors in the striatum of BTBR mice: Novel insights into the pathophysiology of adult idiopathic forms of autism spectrum disorders.
Sign Up to like & getrecommendations! Published in 2022 at "Current neuropharmacology"
DOI: 10.2174/1567202619999220209112609
Abstract: mGlu5 metabotropic glutamate receptors are considered as candidate drug targets in the treatment of "monogenic" forms of autism spectrum disorders (ASD), such as Fragile-X syndrome (FXS). However, despite promising preclinical data, clinical trials using mGlu5… read more here.
Keywords: idiopathic forms; expression; btbr mice; mglu5 ... See more keywords