Bacterial DNA promoting inflammation via the Sgk1/Nedd4L/Syk pathway in mast cells contributes to antihistamine non-responsive CSU.
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DOI: 10.1093/jleuko/qiad025
Abstract: Inflammation centered on non-IgE-mediated mast cell activation characterizes chronic spontaneous urticaria (CSU) resistant to non-sedating H1-antihistamines (nsAH). We recently uncovered a strong positive association between inflammation and the fecal Escherichia. To further explore the actions… read more here.
Keywords: inflammation; mast; btdna; bacterial dna ... See more keywords