Abstract 3232: Development of novel Btk inhibitor, CB988 targering ibrutinib-resistant Btk C481S mutant
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DOI: 10.1158/1538-7445.am2017-3232
Abstract: Introduction: Bruton9s tyrosine kinase (Btk) is a member of the Tec family of cytoplasmic tyrosine kinase. Btk plays a crucial role in the BCR signaling, essential for B-cell development, and Btk has been recognized as… read more here.
Keywords: inhibitor cb988; btk c481s; btk; btk inhibitor ... See more keywords
Gene Editing of BTK in Acute Myeloid Leukaemia Using CRISPR-Cas9
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DOI: 10.1182/blood-2018-99-113804
Abstract: Acute myeloid leukemia (AML) blood cancer is found primarily in adults and the elderly, being the third biggest blood cancer killer. In the last decades there has been some improved rates in younger patients, but… read more here.
Keywords: btk c481s; btk; aml; cell ... See more keywords