MOLECULAR MECHANISMS AND COMBINATION STRATEGIES WITH PI3K AND BTK INHIBITORS TO OVERCOME INTRINSIC AND ACQUIRED RESISTANCE IN PRECLINICAL MODELS OF ABC‐DLBCL
Sign Up to like & getrecommendations! Published in 2017 at "Hematological Oncology"
DOI: 10.1002/hon.2439_179
Abstract: The Bruton's tyrosine kinase (Btk) inhibitor ibrutinib has demonstrated promising efficacy in a variety of hematologic malignancies. However, the precise mechanism of action of the drug remains to be fully elucidated. Tumor‐infiltrating macrophages presented in… read more here.
Keywords: inhibitor; mechanisms combination; combination strategies; btk inhibitor ... See more keywords
Use of BTK inhibitors with special focus on ibrutinib in Waldenström macroglobulinemia: An expert panel opinion statement
Sign Up to like & getrecommendations! Published in 2022 at "Hematological Oncology"
DOI: 10.1002/hon.2982
Abstract: The pivotal role that ibrutinib plays in the management of Waldenström macroglobulinemia (WM) is undisputed but there are ongoing questions regarding its positioning in the therapeutic algorithm of WM as well as in some peculiar… read more here.
Keywords: use btk; ibrutinib; waldenstr macroglobulinemia; panel ... See more keywords
Use of BTK inhibitors with focus on ibrutinib in mantle cell lymphoma: an expert panel opinion statement.
Sign Up to like & getrecommendations! Published in 2022 at "Hematological oncology"
DOI: 10.1002/hon.2983
Abstract: The introduction of BTK inhibitors transformed the management of patients with mantle cell lymphoma (MCL). Ibrutinib, the first-in-class BTK inhibitor is now approved in more than 80 countries and there are over 20 new BTK… read more here.
Keywords: opinion statement; mantle cell; cell lymphoma; btk inhibitors ... See more keywords
Structural optimization of diphenylpyrimidine derivatives (DPPYs) as potent Bruton's tyrosine kinase (BTK) inhibitors with improved activity toward B leukemia cell lines.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.11.047
Abstract: A new series of diphenylpyrimidine derivatives (DPPYs) bearing various aniline side chains at the C-2 position of pyrimidine core were synthesized as potent BTK inhibitors. Most of these inhibitors displayed improved activity against B leukemia… read more here.
Keywords: improved activity; derivatives dppys; diphenylpyrimidine derivatives; btk inhibitors ... See more keywords
The development of Bruton's tyrosine kinase (BTK) inhibitors from 2012 to 2017: A mini-review.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.03.062
Abstract: Bruton's tyrosine kinase (BTK) has emerged as a promising drug target for multiple diseases, particularly haematopoietic malignancies and autoimmune diseases related to B lymphocytes. This review focuses on the diverse, small-molecule inhibitors of BTK kinase… read more here.
Keywords: btk; kinase btk; btk inhibitors; bruton tyrosine ... See more keywords
Emerging small-molecule inhibitors of the Bruton's tyrosine kinase (BTK): Current development.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113329
Abstract: Therapy based on Bruton's tyrosine kinase (BTK) inhibitors one of the major treatment options currently recommended for lymphoma patients. The first generation of BTK inhibitor, Ibrutinib, achieved remarkable progress in the treatment of B-cell malignancies,… read more here.
Keywords: development; btk; kinase btk; btk inhibitors ... See more keywords
Btk Inhibitors as First Oral Atherothrombosis-Selective Antiplatelet Drugs?
Sign Up to like & getrecommendations! Published in 2019 at "Thrombosis and haemostasis"
DOI: 10.1055/s-0039-1687877
Abstract: Bruton's tyrosine kinase (Btk) is essential for B cell differentiation and proliferation, but also platelets express Btk. Patients with X-linked agammaglobulinemia due to hereditary Btk deficiency do not show bleeding, but a mild bleeding tendency… read more here.
Keywords: antiplatelet drugs; first oral; inhibitors first; btk ... See more keywords
A rationale for blocking thromboinflammation in COVID-19 with Btk inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Platelets"
DOI: 10.1080/09537104.2020.1775189
Abstract: A novel Coronavirus infection (COVID-19) leading to pneumonia and severe acute respiratory distress syndrome (ARDS) was first reported in Wuhan, Hubei Province, China in December 2019 and has subse... read more here.
Keywords: thromboinflammation covid; covid btk; rationale blocking; covid ... See more keywords
Structure-based virtual screening and biological evaluation of novel small-molecule BTK inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2021.1999237
Abstract: Abstract Bruton tyrosine kinase (BTK) is linked to multiple signalling pathways that regulate cellular survival, activation, and proliferation. A covalent BTK inhibitor has shown favourable outcomes for treating B cell malignant leukaemia. However, covalent inhibitors… read more here.
Keywords: inhibitor; btk inhibitor; based virtual; btk inhibitors ... See more keywords
Cardiotoxicity of BTK inhibitors: ibrutinib and beyond
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Hematology"
DOI: 10.1080/17474086.2022.2067526
Abstract: ABSTRACT Introduction The development of Brutons Tyrosine Kinase (BTK) inhibitors has transformed the treatment of B-cell malignancies and other non-malignant conditions. Management of the unique cardiotoxic profile of these agents requires prompt recognition and a… read more here.
Keywords: btk inhibitor; btk; cardiotoxicity btk; inhibitors ibrutinib ... See more keywords
Zanubrutinib in lymphoproliferative disorders: a comprehensive review
Sign Up to like & getrecommendations! Published in 2022 at "Therapeutic Advances in Hematology"
DOI: 10.1177/20406207221093980
Abstract: The availability of Bruton tyrosine kinase (BTK) inhibitors has brought about a paradigm shift in the treatment of patients with B-cell lymphomas and chronic lymphocytic leukemia. BTK was clinically validated as a target by the… read more here.
Keywords: btk inhibitor; btk; side effects; treatment ... See more keywords