Bortezomib‐Encapsulated Dual Responsive Copolymeric Nanoparticles for Gallbladder Cancer Targeted Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202103895
Abstract: Gallbladder cancer (GBC) is a rare but the most malignant type of biliary tract tumor. It is usually diagnosed at an advanced stage and conventional treatments are unsatisfactory. As a proteasome inhibitor, bortezomib (BTZ) exhibits… read more here.
Keywords: copolymeric nanoparticles; responsive copolymeric; targeted therapy; btz ... See more keywords
A Defect-Free Naphthalene Diimide Bithiazole Copolymer via Regioselective Direct Arylation Polycondensation
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201800821
Abstract: An optimized direct arylation polycondensation (DAP) protocol for the synthesis of a novel naphthalene diimide (NDI) 2,2'-bithiazole (2-BTz) copolymer (PNDI-2-BTz) is presented. The regioselective C-H activation of 2-BTz at the 5-positions allows for the synthesis… read more here.
Keywords: direct arylation; arylation polycondensation; naphthalene diimide; btz ... See more keywords
Mechanisms underlying synergism between circularized tumor necrosis factor‐related apoptosis inducing ligand and bortezomib in bortezomib‐sensitive or ‐resistant myeloma cells
Sign Up to like & getrecommendations! Published in 2022 at "Hematological Oncology"
DOI: 10.1002/hon.3045
Abstract: Mechanisms underlying interactions between a novel, clinically relevant circularized tumor necrosis factor‐related apoptosis inducing ligand (TRAIL) agonist, circularly permuted TRAIL (CPT) have been examined in multiple myeloma (MM) cells sensitive or resistant to bortezomib (BTZ).… read more here.
Keywords: necrosis factor; bortezomib; apoptosis; tumor necrosis ... See more keywords
Effect of Lipoic Acid on the Biochemical Mechanisms of Resistance to Bortezomib in SH-SY5Y Neuroblastoma Cells
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0575-6
Abstract: Neuroblastoma (NB) is an extracranial solid cancer and the most common cancer in infancy. Despite the standard treatment for NB is based on the combination of chemotherapeutic drugs such as doxorubicin, vincristine, cyclophosphamide, and cisplatin,… read more here.
Keywords: cell viability; effect; btz; stress ... See more keywords
High-Mobility Low-Hysteresis Electrolyte-Gated Transistors with a DPP-Benzotriazole Copolymer Semiconductor
Sign Up to like & getrecommendations! Published in 2020 at "Macromolecular Research"
DOI: 10.1007/s13233-020-8120-2
Abstract: High-mobility low-hysteresis electrolyte-gated thin-film transistors were successfully fabricated using a diketopyrrolopyrrole (DPP) and benzotriazole (BTz) copolymer semiconductor and high-capacitance ion gels based on 1-ethyl-3-methylimidazolium bis[(trifluoromethyl)sulfonyl]imide ([EMI][TFSI]) and tetraoctyl phosphonium ([P 8888 ]) [TFSI]. The DPP-BTz… read more here.
Keywords: mobility; semiconductor; hysteresis; electrolyte gated ... See more keywords
Biotinylated HPMA Centered Polymeric Nanoparticles for Bortezomib Delivery.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119173
Abstract: Bortezomib (BTZ) is a proteasome inhibitor as approved by US FDA for the treatment of multiple myeloma. It exhibits significant anti-cancer properties including against solid tumors; but lacks aqueous solubility, chemical stability which hinders its… read more here.
Keywords: polymeric nanoparticles; biotinylated hpma; delivery; hpma ... See more keywords
PEGylated Dendrimer Mediated Delivery of Bortezomib: Drug Conjugation versus Encapsulation.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119389
Abstract: Poor aqueous solubility of anticancer drug bortezomib (BTZ) still remain a major challenge in the successful formulation development. The dendrimeric platform can provide an opportunity to deliver BTZ with improved solubility. BTZ encapsulated in PEGylated… read more here.
Keywords: drug; btz peg; peg pamam; btz ... See more keywords
MiR-197-3p reduces bortezomib resistance in multiple myeloma by inhibiting IL-6 expression in a MEAF6-dependent manner.
Sign Up to like & getrecommendations! Published in 2022 at "Leukemia research"
DOI: 10.1016/j.leukres.2022.106785
Abstract: OBJECTIVE This study investigated the mechanism by which miR-197-3p regulated IL-6 expression and reduced bortezomib (BTZ) resistance in multiple myeloma (MM). METHODS The expression of miR-197-3p, MEAF6 and IL-6 in BTZ-resistant MM cells was measured.… read more here.
Keywords: expression; resistance multiple; multiple myeloma; mir 197 ... See more keywords
Foe to Friend: Supramolecular Nanomedicines Consisting of Natural Polyphenols and Bortezomib.
Sign Up to like & getrecommendations! Published in 2018 at "Nano letters"
DOI: 10.1021/acs.nanolett.8b03015
Abstract: Bortezomib (BTZ) is a first-in-class boronate proteasome inhibitor used for cancer therapy, but its therapeutic efficacy is usually inhibited by dietary polyphenols due to boronate-catechol complexation. Benefiting from such dynamic covalent chemistry, herein we describe… read more here.
Keywords: foe friend; supramolecular nanomedicines; friend supramolecular; consisting natural ... See more keywords
Injectable Coacervate Hydrogel for Delivery of Anticancer Drug-Loaded Nanoparticles in vivo.
Sign Up to like & getrecommendations! Published in 2018 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.7b14319
Abstract: In this study, bortezomib (BTZ, a cytotoxic water-insoluble anticancer drug) was encapsulated in micellar nanoparticles having a catechol-functionalized polycarbonate core through a pH-sensitive covalent bond between phenylboronic acid (PBA) in BTZ and catechol, and these… read more here.
Keywords: drug loaded; hydrogel; delivery; drug ... See more keywords
Investigating Intestinal Permeability of Bortezomib Using a Validated HPLC-UV Method.
Sign Up to like & getrecommendations! Published in 2019 at "Drug research"
DOI: 10.1055/s-0043-115648
Abstract: Bortezomib (BTZ), as a proteasome inhibitor, has been used for treatment of patients with relapsed/refractory multiple myeloma and mantle cell lymphoma. BTZ is available for intravenous injection or subcutaneous administration. In this study, for evaluating… read more here.
Keywords: intestinal permeability; using validated; permeability; validated hplc ... See more keywords