Bub1 kinase in the regulation of mitosis
Sign Up to like & getrecommendations! Published in 2021 at "Animal Cells and Systems"
DOI: 10.1080/19768354.2021.1884599
Abstract: ABSTRACT Accurate chromosome segregation is required for cell survival and organismal development. During mitosis, the spindle assembly checkpoint acts as a safeguard to maintain the high fidelity of mitotic chromosome segregation by monitoring the attachment… read more here.
Keywords: bub1; mitosis; spindle assembly; bub1 kinase ... See more keywords
Abstract 287: BAY 1816032, a novel BUB1 kinase inhibitor with potent antitumor activity
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-287
Abstract: The spindle assembly checkpoint represents a highly conserved surveillance mechanism which safeguards correct chromosome segregation by delaying anaphase onset until all chromosomes are properly bi-oriented on the spindle apparatus. Non-catalytic functions of the mitotic kinase… read more here.
Keywords: kinase inhibitor; bub1 kinase; bay 1816032; bub1 ... See more keywords
Abstract 3430: TGFBR2 mediated phosphorylation of BUB1 at Ser-318 is required for transforming growth factor-β signaling
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs18-3430
Abstract: The Ser/Thr kinase BUB1 (budding uninhibited by benzimidazoles-1) is required for efficient signaling by the TGF-β receptor. Recruitment of BUB1 to the activated heteromeric TGF-β-receptor complex including SMAD2 and SMAD3, is required for ligand mediated… read more here.
Keywords: tgfbr2 mediated; phosphorylation bub1; bub1; mediated phosphorylation ... See more keywords
Yeast Fin1-PP1 dephosphorylates an Ipl1 substrate, Ndc80, to remove Bub1-Bub3 checkpoint proteins from the kinetochore during anaphase
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1009592
Abstract: The spindle assembly checkpoint (SAC) prevents anaphase onset in response to chromosome attachment defects, and SAC silencing is essential for anaphase onset. Following anaphase onset, activated Cdc14 phosphatase dephosphorylates the substrates of cyclin-dependent kinase to… read more here.
Keywords: bub1; anaphase; pp1; fin1 pp1 ... See more keywords
Molecular mechanism of Mad1 kinetochore targeting by phosphorylated Bub1
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DOI: 10.15252/embr.202052242
Abstract: Abstract During metaphase, in response to improper kinetochore‐microtubule attachments, the spindle assembly checkpoint (SAC) activates the mitotic checkpoint complex (MCC), an inhibitor of the anaphase‐promoting complex/cyclosome (APC/C). This process is orchestrated by the kinase Mps1,… read more here.
Keywords: bub1; mad1 kinetochore; mad1; phosphorylated bub1 ... See more keywords
bub1 as a potential oncogene and a prognostic biomarker for neuroblastoma
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DOI: 10.3389/fonc.2022.988415
Abstract: Background Neuroblastoma is the most common malignant extracranial tumor for children. Molecular mechanisms underpinning the pathogenesis of this disease are yet to be fully clarified. This study aimed to identify a novel oncogene that could… read more here.
Keywords: expression; prognostic biomarker; neuroblastoma; bub1 ... See more keywords
BUB1 Is Identified as a Potential Therapeutic Target for Pancreatic Cancer Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Public Health"
DOI: 10.3389/fpubh.2022.900853
Abstract: Pancreatic cancer is one of the most challenging cancer types in clinical treatment worldwide. This study aimed to understand the tumorigenesis mechanism and explore potential therapeutic targets for patients with pancreatic cancer. Single-cell data and… read more here.
Keywords: cell; therapeutic target; pancreatic cancer; bub1 ... See more keywords