Bub1 kinase in the regulation of mitosis
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DOI: 10.1080/19768354.2021.1884599
Abstract: ABSTRACT Accurate chromosome segregation is required for cell survival and organismal development. During mitosis, the spindle assembly checkpoint acts as a safeguard to maintain the high fidelity of mitotic chromosome segregation by monitoring the attachment… read more here.
Keywords: bub1; mitosis; spindle assembly; bub1 kinase ... See more keywords
Inhibition of BUB1 Kinase by BAY 1816032 Sensitizes Tumor Cells toward Taxanes, ATR, and PARP Inhibitors In Vitro and In Vivo
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DOI: 10.1158/1078-0432.ccr-18-0628
Abstract: Purpose: The catalytic function of BUB1 is required for chromosome arm resolution and positioning of the chromosomal passenger complex for resolution of spindle attachment errors and plays only a minor role in spindle assembly checkpoint… read more here.
Keywords: parp inhibitors; bay 1816032; atr parp; bub1 kinase ... See more keywords
Abstract 287: BAY 1816032, a novel BUB1 kinase inhibitor with potent antitumor activity
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DOI: 10.1158/1538-7445.am2017-287
Abstract: The spindle assembly checkpoint represents a highly conserved surveillance mechanism which safeguards correct chromosome segregation by delaying anaphase onset until all chromosomes are properly bi-oriented on the spindle apparatus. Non-catalytic functions of the mitotic kinase… read more here.
Keywords: kinase inhibitor; bub1 kinase; bay 1816032; bub1 ... See more keywords