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   Articles with "bub3" as a keyword



YY2/BUB3 Axis promotes SAC Hyperactivation and Inhibits Colorectal Cancer Progression via Regulating Chromosomal Instability

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202308690

Abstract: Spindle assembly checkpoint (SAC) is a crucial safeguard mechanism of mitosis fidelity that ensures equal division of duplicated chromosomes to the two progeny cells. Impaired SAC can lead to chromosomal instability (CIN), a well‐recognized hallmark… read more here.

Keywords: sac; chromosomal instability; bub3; tumor ... See more keywords

The long noncoding RNA CRYBG3 induces aneuploidy by interfering with spindle assembly checkpoint via direct binding with Bub3

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recommendations! Published in 2021 at "Oncogene"

DOI: 10.1038/s41388-020-01601-8

Abstract: Aneuploidy is a hallmark of genomic instability that leads to tumor initiation, progression, and metastasis. CDC20, Bub1, and Bub3 form the mitosis checkpoint complex (MCC) that binds the anaphase-promoting complex or cyclosome (APC/C), a crucial… read more here.

Keywords: spindle assembly; crybg3; lnc crybg3; bub3 ... See more keywords

Yeast Fin1-PP1 dephosphorylates an Ipl1 substrate, Ndc80, to remove Bub1-Bub3 checkpoint proteins from the kinetochore during anaphase

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recommendations! Published in 2021 at "PLoS Genetics"

DOI: 10.1371/journal.pgen.1009592

Abstract: The spindle assembly checkpoint (SAC) prevents anaphase onset in response to chromosome attachment defects, and SAC silencing is essential for anaphase onset. Following anaphase onset, activated Cdc14 phosphatase dephosphorylates the substrates of cyclin-dependent kinase to… read more here.

Keywords: bub1; anaphase; pp1; fin1 pp1 ... See more keywords

BUB3, beyond the Simple Role of Partner

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recommendations! Published in 2022 at "Pharmaceutics"

DOI: 10.3390/pharmaceutics14051084

Abstract: The BUB3 protein plays a key role in the activation of the spindle assembly checkpoint (SAC), a ubiquitous surveillance mechanism that ensures the fidelity of chromosome segregation in mitosis and, consequently, prevents chromosome mis-segregation and… read more here.

Keywords: simple role; role partner; bub3; role ... See more keywords

Arrest of Cell Cycle by Avian Reovirus p17 through Its Interaction with Bub3

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recommendations! Published in 2022 at "Viruses"

DOI: 10.3390/v14112385

Abstract: Avian reoviruses (ARV) are a group of poultry pathogens that cause runting and stunting syndrome (RSS), a condition otherwise known as “frozen chicken”, which are characterized by dramatically delayed growth in broilers. It has been… read more here.

Keywords: cell; arrest; bub3; cell cycle ... See more keywords