The long noncoding RNA CRYBG3 induces aneuploidy by interfering with spindle assembly checkpoint via direct binding with Bub3
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-020-01601-8
Abstract: Aneuploidy is a hallmark of genomic instability that leads to tumor initiation, progression, and metastasis. CDC20, Bub1, and Bub3 form the mitosis checkpoint complex (MCC) that binds the anaphase-promoting complex or cyclosome (APC/C), a crucial… read more here.
Keywords: spindle assembly; crybg3; lnc crybg3; bub3 ... See more keywords
Yeast Fin1-PP1 dephosphorylates an Ipl1 substrate, Ndc80, to remove Bub1-Bub3 checkpoint proteins from the kinetochore during anaphase
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1009592
Abstract: The spindle assembly checkpoint (SAC) prevents anaphase onset in response to chromosome attachment defects, and SAC silencing is essential for anaphase onset. Following anaphase onset, activated Cdc14 phosphatase dephosphorylates the substrates of cyclin-dependent kinase to… read more here.
Keywords: bub1; anaphase; pp1; fin1 pp1 ... See more keywords
BUB3, beyond the Simple Role of Partner
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DOI: 10.3390/pharmaceutics14051084
Abstract: The BUB3 protein plays a key role in the activation of the spindle assembly checkpoint (SAC), a ubiquitous surveillance mechanism that ensures the fidelity of chromosome segregation in mitosis and, consequently, prevents chromosome mis-segregation and… read more here.
Keywords: simple role; role partner; bub3; role ... See more keywords
Arrest of Cell Cycle by Avian Reovirus p17 through Its Interaction with Bub3
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DOI: 10.3390/v14112385
Abstract: Avian reoviruses (ARV) are a group of poultry pathogens that cause runting and stunting syndrome (RSS), a condition otherwise known as “frozen chicken”, which are characterized by dramatically delayed growth in broilers. It has been… read more here.
Keywords: cell; arrest; bub3; cell cycle ... See more keywords