Nearly complete deletion of BubR1 causes microcephaly through shortened mitosis and massive cell death.
Sign Up to like & getrecommendations! Published in 2019 at "Human molecular genetics"
DOI: 10.1093/hmg/ddz022
Abstract: BUB-related 1 (BubR1) encoded by Budding Uninhibited by Benzimidazole 1B (BUB1B) is a crucial mitotic checkpoint protein ensuring proper segregation of chromosomes during mitosis. Mutations of BUB1B are responsible for mosaic variegated aneuploidy (MVA), a… read more here.
Keywords: shortened mitosis; mitosis; bubr1; cell death ... See more keywords
Age‐related decline in BubR1 impairs adult hippocampal neurogenesis
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DOI: 10.1111/acel.12594
Abstract: Aging causes significant declines in adult hippocampal neurogenesis and leads to cognitive disability. Emerging evidence demonstrates that decline in the mitotic checkpoint kinase BubR1 level occurs with natural aging and induces progeroid features in both… read more here.
Keywords: age related; neurogenesis; hippocampal neurogenesis; adult hippocampal ... See more keywords
Sirt2‐BubR1 acetylation pathway mediates the effects of advanced maternal age on oocyte quality
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DOI: 10.1111/acel.12698
Abstract: The level of Sirt2 protein is reduced in oocytes from aged mice, while exogenous expression of Sirt2 could ameliorate the maternal age‐associated meiotic defects. To date, the underlying mechanism remains unclear. Here, we confirmed that… read more here.
Keywords: acetylation; mediates effects; sirt2; bubr1 ... See more keywords
BubR1 Insufficiency Impairs Affective Behavior and Memory Function in Mice
Sign Up to like & getrecommendations! Published in 2018 at "International Neurourology Journal"
DOI: 10.5213/inj.1836218.109
Abstract: Purpose Although aging causes functional declines in cognition, the molecular mechanism underlying these declines remains largely unknown. Recently, the spindle checkpoint kinase budding uninhibited by benzimidazole-related 1 (BubR1) has emerged as a key determinant for… read more here.
Keywords: memory function; like behavior; bubr1; test ... See more keywords