Tricyclic pyrazolo[1,5-d][1,4]benzoxazepin-5(6H)-one scaffold derivatives: Synthesis and biological evaluation as selective BuChE inhibitors.
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DOI: 10.1016/j.ejmech.2018.02.002
Abstract: BuChE inhibitors play important roles in treatment of patients with advanced Alzheimer's disease (AD). A series of tricyclic pyrazolo[1,5-d][1,4]benzoxazepin-5(6H)-one derivatives were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors. Some derivatives showed selective… read more here.
Keywords: tricyclic pyrazolo; buche inhibitors; selective buche; buche ... See more keywords
A patent review of butyrylcholinesterase inhibitors and reactivators 2010–2017
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DOI: 10.1080/13543776.2018.1476494
Abstract: ABSTRACT Introduction: Butyrylcholinesterase (BuChE) has obtained a renewed interest as therapeutic target in Alzheimer’s disease (AD), when changes in BuChE activity and expression along disease progression were highlighted as well as correlation between BuChE levels… read more here.
Keywords: patent review; butyrylcholinesterase; buche inhibitors; buche ... See more keywords