Idarubicin plus BuCy versus BuCy conditioning regimens for intermediate‐risk acute myeloid leukemia in first complete remission undergoing auto‐HSCT: An open‐label, multicenter, randomized phase 3 trial
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DOI: 10.1002/ajh.26800
Abstract: We report a randomized prospective phase 3 study, designed to evaluate the efficacy and tolerability of idarubicin plus busulfan and cyclophosphamide (IDA‐BuCy) versus BuCy in autologous hematopoietic stem‐cell transplantation (auto‐HSCT) for intermediate‐risk acute myeloid leukemia… read more here.
Keywords: ida bucy; bucy; auto hsct;
Integrated multi-omics study identifies ursolic acid as a novel therapeutic agent targeting the TNF-α/TAK1/IKKβ/NF-κB axis in hepatic sinusoidal obstruction syndrome
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DOI: 10.1182/blood-2025-4091
Abstract: Hepatic sinusoidal obstruction syndrome (SOS) is a lethal complication of hematopoietic stem cell transplantation (HSCT) with limited targeted therapies. The busulfan-cyclophosphamide (BUCY) conditioning regimen induces endothelial injury, thereby initiating a thromboinflammatory cascade. While TNF-α/NF-κB signaling… read more here.
Keywords: bucy; tak1 ikk; tnf; p65 ... See more keywords