Bufalin induces apoptosis and autophagy via the Ca2+/CaMKKβ/AMPK/Beclin1 signaling pathway in osteosarcoma cells.
Sign Up to like & getrecommendations! Published in 2023 at "Cell biology international"
DOI: 10.1002/cbin.12021
Abstract: Bufalin, a major cardiotonic compound of the traditional Chinese medicine Chanshu has been used for cancer treatment for several years. However, the molecular mechanisms of Bufalin-induced autophagy in osteosarcoma (OS) is not fully understood. In… read more here.
Keywords: ampk beclin1; apoptosis autophagy; bufalin; bufalin induced ... See more keywords
The sodium pump α1 subunit regulates bufalin sensitivity of human glioblastoma cells through the p53 signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-019-09462-y
Abstract: Bufalin is the primary component of the traditional Chinese medicine “Chan Su,” which has been widely used for cancer treatment at oncology clinics in certain countries. Evidence suggests that this compound possesses potent antitumor activities,… read more here.
Keywords: bufalin; p53 signaling; glioma; sensitivity ... See more keywords
Unique Oxidative Metabolism of Bufalin Generates Two Reactive Metabolites That Strongly Inactivate Human Cytochrome P450 3A.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01875
Abstract: Identifying the alert groups of mechanism-based inactivators of human cytochrome P450s (hCYPs) is very helpful for early prediction of drug toxicity and for rational drug design to avoid idiosyncratic toxicity. Here, we report that a… read more here.
Keywords: human cytochrome; oxidative metabolism; unique oxidative; bufalin ... See more keywords
Bufalin stimulates antitumor immune response by driving tumor-infiltrating macrophage toward M1 phenotype in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-004297
Abstract: Background Immunotherapy for hepatocellular carcinoma (HCC) exhibits limited clinical efficacy due to immunosuppressive tumor microenvironment (TME). Tumor-infiltrating macrophages (TIMs) account for the major component in the TME, and the dominance of M2 phenotype over M1… read more here.
Keywords: antitumor immune; hcc; bufalin; immune response ... See more keywords
Alisol B 23-Acetate Increases the Antitumor Effect of Bufalin on Liver Cancer through Inactivating Wnt/β-Catenin Axis
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/6249534
Abstract: Objective Liver cancer seriously threatens the health of people. Meanwhile, it has been reported that bufalin could act as an inhibitor in liver cancer. In addition, alisol B 23-acetate is a natural product derived from… read more here.
Keywords: liver cancer; effect; alisol acetate; bufalin ... See more keywords
Bufalin, a Traditional Chinese Medicine Compound, Prevents Tumor Formation in Two Murine Models of Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Prevention Research"
DOI: 10.1158/1940-6207.capr-19-0134
Abstract: Chemoprevention is cost-effective for colorectal cancer when targeted at intermediate- or high-risk populations. Bufalin is a cardiac glycoside extracted from the traditional Chinese medicine (TCM) “Chan Su,” which has been used as an anticancer agent.… read more here.
Keywords: medicine; cancer; bufalin; chinese medicine ... See more keywords
Bufalin-loaded bovine serum albumin nanoparticles demonstrated improved anti-tumor activity against hepatocellular carcinoma: preparation, characterization, pharmacokinetics and tissue distribution.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18800
Abstract: OBJECTIVE To prepare and evaluate the liver-targeted drug delivery system of Bufalin with higher liver uptake and stronger antitumor activity against hepatocellular carcinoma. METHODS Bufalin-loaded bovine serum albumin nanoparticle was prepared by desolvation method, to… read more here.
Keywords: loaded bovine; bufalin; bufalin loaded; serum albumin ... See more keywords
Bufalin inhibits epithelial-mesenchymal transition and increases radiosensitivity of non-small cell lung cancer via inhibition of the Src signaling
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Thoracic Disease"
DOI: 10.21037/jtd-22-1859
Abstract: Background Epithelial-mesenchymal transition (EMT) is a biological process involved in tumor migration, invasion, and radiotherapy resistance. Bufalin can affect the proliferation, apoptosis and invasion of tumor cells by regulating multiple signaling pathways. Whether bufalin can… read more here.
Keywords: cell; src signaling; bufalin; invasion ... See more keywords
Bufalin suppresses esophageal squamous cell carcinoma progression by activating the PIAS3/STAT3 signaling pathway
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Thoracic Disease"
DOI: 10.21037/jtd-23-486
Abstract: Background Esophageal cancer, especially esophageal squamous cell carcinoma (ESCC), is a common malignant tumor of the digestive tract. Bufalin is an effective anti-tumor compound. However, little is known about the regulatory mechanisms of Bufalin in… read more here.
Keywords: cell; proliferation; stat3; bufalin ... See more keywords
The Research Progress of Bufalin in the Treatment of Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "OncoTargets and therapy"
DOI: 10.2147/ott.s333233
Abstract: Abstract Hepatocellular carcinoma (HCC) is one of the deadliest cancers in the world with a five-year survival rate of less than 20%. Nonetheless, selecting an appropriate therapeutic agent to inhibit the development of hepatoma cells… read more here.
Keywords: hepatocellular carcinoma; bufalin; progress bufalin; research progress ... See more keywords
Combination Treatment of Sorafenib and Bufalin Induces Apoptosis in NCI-H292 Human Lung Cancer Cells In Vitro
Sign Up to like & getrecommendations! Published in 2022 at "In Vivo"
DOI: 10.21873/invivo.12741
Abstract: Background/Aim: Lung cancer notably contributes to tumor-associated mortality worldwide, and standard chemotherapy is used for lung cancer patients. However, its therapeutic efficacy remains unsatisfactory. This study aimed to evaluate the effects and molecular mechanisms of… read more here.
Keywords: lung cancer; nci h292; sorafenib bufalin; combination ... See more keywords