Measuring pH and Buffer Capacity in Fluids Aspirated from the Fasted Upper Gastrointestinal Tract of Healthy Adults
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutical Research"
DOI: 10.1007/s11095-019-2731-3
Abstract: Purpose The design of biorelevant conditions for in vitro evaluation of orally administered drug products is contingent on obtaining accurate values for physiologically relevant parameters such as pH, buffer capacity and bile salt concentrations in… read more here.
Keywords: gastrointestinal tract; capacity; upper gastrointestinal; buffer capacity ... See more keywords
Imaging Sample Acidification Triggered by Electrochemically Activated Polyaniline
Sign Up to like & getrecommendations! Published in 2022 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.2c03409
Abstract: In this letter, we demonstrate 2D acidification of samples at environmental and physiological pH with an electrochemically activated polyaniline (PANI) mesh. A novel sensor–actuator concept is conceived for such a purpose. The sample is sandwiched… read more here.
Keywords: imaging sample; acidification; buffer capacity; electrochemically activated ... See more keywords
Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b00426
Abstract: In this study, we determined the pH and buffer capacity of human gastrointestinal (GI) fluids (aspirated from the stomach, duodenum, proximal jejunum, and mid/distal jejunum) as a function of time, from 37 healthy subjects after… read more here.
Keywords: capacity; buffer capacity; low buffer; tract ... See more keywords
Measuring and simulating pH buffer capacity of calcareous soils using empirical and mechanistic models
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DOI: 10.1080/03650340.2019.1628344
Abstract: ABSTRACT We studied (i) the pH buffer capacity (pHBC) of calcareous soils varied widely in calcite and texture, (ii) the contribution of soil properties to pHBC and (iii) the significance of using a model based… read more here.
Keywords: calcite dissolution; buffer capacity; calcareous soils; measuring simulating ... See more keywords
Analysis of tandem queues with finite buffer capacity
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DOI: 10.1080/24725854.2017.1342055
Abstract: ABSTRACT Tandem queues with finite buffer capacity commonly exist in practical applications. By viewing a tandem queue as an integrated system, an innovative approach has been developed to analyze its performance through insight from Friedman's… read more here.
Keywords: tandem queues; finite buffer; tandem; buffer capacity ... See more keywords
Comparative Study of Salivary pH, Buffer Capacity, and Flow in Patients with and without Gastroesophageal Reflux Disease
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph19010201
Abstract: The oral cavity has specific and individualized characteristics, with pH, saliva flow, buffer capacity, temperature, and microorganisms content influencing oral health. Currently, the prevalence of gastroesophageal reflux disease (GERD) is constantly increasing. The objective of… read more here.
Keywords: study; gastroesophageal reflux; buffer capacity; salivary buffer ... See more keywords