Predicting clone genotypes from tumor bulk sequencing of multiple samples
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DOI: 10.1093/bioinformatics/bty469
Abstract: Motivation Analyses of data generated from bulk sequencing of tumors have revealed extensive genomic heterogeneity within patients. Many computational methods have been developed to enable the inference of genotypes of tumor cell populations (clones) from… read more here.
Keywords: tumor samples; clone genotypes; genotypes tumor; bulk sequencing ... See more keywords
PhISCS: a combinatorial approach for subperfect tumor phylogeny reconstruction via integrative use of single-cell and bulk sequencing data
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DOI: 10.1101/gr.234435.118
Abstract: Available computational methods for tumor phylogeny inference via single-cell sequencing (SCS) data typically aim to identify the most likely perfect phylogeny tree satisfying the infinite sites assumption (ISA). However, the limitations of SCS technologies including… read more here.
Keywords: tumor phylogeny; sequencing data; bulk sequencing; phylogeny ... See more keywords
Single-Cell Mutational Profiling Describes the Molecular Heterogeneity of Clonal Evolution in MDS during Therapy and Relapse
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DOI: 10.1182/blood-2018-99-120368
Abstract: Background: Myelodysplastic syndromes (MDS) are a collection of clonal diseases of dysfunctional hematopoietic stem cells, characterized by ineffective hematopoiesis, cytopenias, and dysplasia. Increased understanding of the mutational landscape of MDS has led to initial improvements… read more here.
Keywords: single cell; evolution; bulk sequencing; mds ... See more keywords