Synthesis and Studies of Bulky Cycloalkyl α,β-Dehydroamino Acids that Enhance Proteolytic Stability.
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DOI: 10.1021/acs.orglett.2c01962
Abstract: Three new bulky cycloalkyl α,β-dehydroamino acids (ΔAAs) have been designed and synthesized. Each residue enhances the rigidity of model peptides and their stability to proteolysis, with larger ring sizes exhibiting greater effects. Peptides containing bulky… read more here.
Keywords: cycloalkyl; bulky cycloalkyl; dehydroamino acids; proteolytic stability ... See more keywords