Bumepamine, a brain-permeant benzylamine derivative of bumetanide, does not inhibit NKCC1 but is more potent to enhance phenobarbital's anti-seizure efficacy
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.09.025
Abstract: ABSTRACT Based on the potential role of Na‐K‐Cl cotransporters (NKCCs) in epileptic seizures, the loop diuretic bumetanide, which blocks the NKCC1 isoforms NKCC1 and NKCC2, has been tested as an adjunct with phenobarbital to suppress… read more here.
Keywords: bumetanide; inhibit nkcc1; brain; anti seizure ... See more keywords
Improved symptoms following bumetanide treatment in children aged 3−6 years with autism spectrum disorder: a randomized, double-blind, placebo-controlled trial
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DOI: 10.1016/j.scib.2021.01.008
Abstract: Abstract With the current limited drug therapy for the core symptoms of autism spectrum disorder (ASD), we herein report a randomized, double-blind, placebo-controlled trial to investigate the efficacy, safety, and potential neural mechanism of bumetanide… read more here.
Keywords: placebo; treatment; spectrum disorder; autism spectrum ... See more keywords
Bumetanide increases Cl--dependent short-circuit current in late distal colon: Evidence for the presence of active electrogenic Cl- absorption
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DOI: 10.1371/journal.pone.0171045
Abstract: Mammalian colonic epithelia consist of cells that are capable of both absorbing and secreting Cl-. The present studies employing Ussing chamber technique identified two opposing short-circuit current (Isc) responses to basolateral bumetanide in rat distal… read more here.
Keywords: bumetanide; late distal; absorptive isc; distal colon ... See more keywords