Pyrrolopyrimidine Bumped Kinase Inhibitors for the Treatment of Cryptosporidiosis.
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DOI: 10.1021/acsinfecdis.0c00803
Abstract: Bumped kinase inhibitors (BKIs) that target Cryptosporidium parvum calcium-dependent protein kinase 1 have been well established as potential drug candidates against cryptosporidiosis. Recently, BKI-1649, with a 7H-pyrrolo[2,3-d]pyrimidin-4-amine, or "pyrrolopyrimidine", central scaffold, has shown improved efficacy… read more here.
Keywords: kinase inhibitors; bumped kinase; pyrrolopyrimidine bumped; inhibitors treatment ... See more keywords
Therapeutic Efficacy of Bumped Kinase Inhibitor 1369 in a Pig Model of Acute Diarrhea Caused by Cryptosporidium hominis
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DOI: 10.1128/aac.00147-18
Abstract: ABSTRACT Recent reports highlighting the global significance of cryptosporidiosis among children have renewed efforts to develop control measures. We evaluated the efficacy of bumped kinase inhibitor (BKI) 1369 in the gnotobiotic piglet model of acute… read more here.
Keywords: bumped kinase; hominis; efficacy bumped; bki 1369 ... See more keywords
Comparison of Toxicities among Different Bumped Kinase Inhibitor Analogs for Treatment of Cryptosporidiosis
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DOI: 10.1128/aac.01425-22
Abstract: Recent advances on the development of bumped kinase inhibitors for treatment of cryptosporidiosis have focused on the 5-aminopyrazole-4-carboxamide scaffold, due to analogs that have less hERG inhibition, superior efficacy, and strong in vitro safety profiles.… read more here.
Keywords: efficacy; treatment cryptosporidiosis; bumped kinase; treatment ... See more keywords