Repurposing of an old drug: In vitro and in vivo efficacies of buparvaquone against Echinococcus multilocularis
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DOI: 10.1016/j.ijpddr.2018.10.011
Abstract: The metacestode stage of the fox tapeworm Echinococcus multilocularis causes the lethal disease alveolar echinococcosis. Current chemotherapeutic treatment options are based on benzimidazoles (albendazole and mebendazole), which are insufficient and hence alternative drugs are needed.… read more here.
Keywords: echinococcus multilocularis; vivo; drug; multilocularis ... See more keywords
Selection of genotypes harbouring mutations in the cytochrome b gene of Theileria annulata is associated with resistance to buparvaquone
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DOI: 10.1371/journal.pone.0279925
Abstract: Buparvaquone remains the only effective therapeutic agent for the treatment of tropical theileriosis caused by Theileria annulata. However, an increase in the rate of buparvaquone treatment failures has been observed in recent years, raising the… read more here.
Keywords: cytochrome gene; resistance; buparvaquone; theileria annulata ... See more keywords
Development and Validation of Stability Indicating Method for Estimation of Buparvaquone by Forced Degradation Studies
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DOI: 10.5530/ijper.54.3.131
Abstract: Aim: A lucid, rapid and precise stability-indicating method was developed by using HPLC for the estimation of Buparvaquone in bulk as well as pharmaceutical dosage form by forced degradation studies. Materials and Methods: Princeton C18… read more here.
Keywords: forced degradation; indicating method; stability indicating; estimation buparvaquone ... See more keywords