Paeoniflorin attenuated bupivacaine‐induced neurotoxicity in SH‐SY5Y cells via suppression of the p38 MAPK pathway
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DOI: 10.1002/jcb.27964
Abstract: Bupivacain, a common local anesthetic, can cause neurotoxicity and permanent neurological disorders. Paeoniflorin has been widely reported as a potential neuroprotective agent in neural injury models. However, the roles and molecular basis of paeoniflorin in… read more here.
Keywords: p38 mapk; p38; bupivacaine induced; sy5y cells ... See more keywords
The protective effect of lipid emulsion in preventing bupivacaine-induced mitochondrial injury and apoptosis of H9C2 cardiomyocytes
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DOI: 10.1080/10717544.2016.1261379
Abstract: Abstract Lipid emulsion (LE) has been shown to be effective in the resuscitation of bupivacaine-induced cardiac arrest, but the precise mechanism of this action has not been fully elucidated. Pursuant to this lack of information… read more here.
Keywords: bupivacaine induced; h9c2 cardiomyocytes; bupivacaine; apoptosis h9c2 ... See more keywords
Transcriptome sequencing combined with bioinformatics predicts potential genes and pathways associated with bupivacaine-induced apoptosis
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DOI: 10.1080/19768354.2017.1287774
Abstract: ABSTRACT This study aimed to explore the potential genes and pathways associated with bupivacaine-induced apoptosis. Human neuroblastoma cell line SH-SY5Y was used in this study. The effect of bupivacaine on cell viability of SH-SY5Y was… read more here.
Keywords: bupivacaine induced; analysis; induced apoptosis; bupivacaine ... See more keywords
Intralipid fails to rescue bupivacaine-induced cardiotoxicity in late-pregnant rats
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DOI: 10.3389/fmed.2022.899036
Abstract: Background Females routinely receive bupivacaine for obstetric and regional anesthesia. An accidental overdose of bupivacaine can result in cardiotoxicity and cardiac arrest. Intralipid (ILP) rescues bupivacaine-induced cardiotoxicity in male rats. However, bupivacaine cardiotoxicity and ILP… read more here.
Keywords: ilp; pregnant rats; cardiotoxicity; late pregnant ... See more keywords