Patient-Reported Outcomes of Treatment of Opioid Dependence With Weekly and Monthly Subcutaneous Depot vs Daily Sublingual Buprenorphine: A Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2021.9041
Abstract: Importance Patient-reported outcomes in the treatment of opioid dependence may differ between subcutaneously administered depot buprenorphine and daily sublingual buprenorphine. Objective To compare patient satisfaction between depot buprenorphine and sublingual buprenorphine in adult outpatients with… read more here.
Keywords: trial; treatment; sublingual buprenorphine; buprenorphine ... See more keywords
Comparative Effectiveness Associated With Buprenorphine and Naltrexone in Opioid Use Disorder and Cooccurring Polysubstance Use
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.11363
Abstract: Key Points Question What is the prevalence and comparative effectiveness associated with buprenorphine and naltrexone in individuals with opioid use disorder (OUD) and cooccurring substance use disorders (SUDs)? Findings This comparative effectiveness study evaluated 179 280… read more here.
Keywords: buprenorphine; effectiveness associated; use; comparative effectiveness ... See more keywords
Buprenorphine Utilization and Prescribing Among New Jersey Medicaid Beneficiaries After Adoption of Initiatives Designed to Improve Treatment Access
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.12030
Abstract: Key Points Question Were initiatives aimed at improving access to buprenorphine treatment in New Jersey Medicaid associated with increases in buprenorphine utilization and prescribing? Findings This cross-sectional study of 20 090 Medicaid beneficiaries found that the… read more here.
Keywords: new jersey; medicaid; buprenorphine; jersey medicaid ... See more keywords
Association Between Buprenorphine Treatment Gaps, Opioid Overdose, and Health Care Spending in US Medicare Beneficiaries With Opioid Use Disorder.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2022.3118
Abstract: Importance Nonadherence to buprenorphine may increase patient risk of opioid overdose and increase health care spending. Quantifying the impacts of nonadherence can help inform clinician practice and policy. Objective To estimate the association between buprenorphine… read more here.
Keywords: buprenorphine treatment; opioid overdose; buprenorphine; treatment ... See more keywords
Association of Patients' Direct Addition of Buprenorphine to Urine Drug Test Specimens With Clinical Factors in Opioid Use Disorder.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2023.0234
Abstract: Importance The direct addition of buprenorphine to urine drug test specimens to mimic results suggestive of adherence is a clinically significant result, yet little is known about the phenomenon. Objective To characterize factors associated with… read more here.
Keywords: buprenorphine urine; direct addition; urine drug; buprenorphine ... See more keywords
Buprenorphine Continuation During Critical Illness Associated With Decreased Inpatient Opioid Utilization In Individuals Maintained On Buprenorphine For Opioid Use Disorder In A Retrospective Study.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of clinical pharmacology"
DOI: 10.1002/jcph.2286
Abstract: The number of patients maintained on buprenorphine is steadily increasing. To date, no study has reported buprenorphine management practices for these patients during critical illness, nor its relationship with supplemental full-agonist opioid administration during their… read more here.
Keywords: buprenorphine; opioid; use; study ... See more keywords
Frontline Science: Buprenorphine decreases CCL2‐mediated migration of CD14+CD16+ monocytes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3hi0118-015r
Abstract: HIV infection of the CNS causes neuroinflammation and damage that contributes to the development of HIV‐associated neurocognitive disorders (HAND) in greater than 50% of HIV‐infected individuals, despite antiretroviral therapy (ART). Opioid abuse is a major… read more here.
Keywords: hiv; cd16 monocytes; cd14 cd16; ccl2 mediated ... See more keywords
Dispersive solid-phase extraction of buprenorphine from biological fluids using metal-organic frameworks and its determination by ultra-performance liquid chromatography.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of separation science"
DOI: 10.1002/jssc.202000221
Abstract: In this work, various types of metal-organic frameworks were synthesized, and their affinities towards buprenorphine were evaluated using dispersive solid-phase extraction. The extracted buprenorphine was determined by ultra-performance liquid chromatography-ultraviolet detection system. The highest extraction… read more here.
Keywords: extraction; metal organic; solid phase; buprenorphine ... See more keywords
Voriconazole greatly increases the exposure to oral buprenorphine
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-018-2548-8
Abstract: PurposeBuprenorphine has low oral bioavailability. Regardless of sublingual administration, a notable part of buprenorphine is exposed to extensive first-pass metabolism by the cytochrome P450 (CYP) 3A4. As drug interaction studies with buprenorphine are limited, we… read more here.
Keywords: exposure oral; voriconazole; increases exposure; buprenorphine ... See more keywords
Comparative study of the efficacy of transdermal buprenorphine patches and prolonged-release tramadol tablets for postoperative pain control after spinal fusion surgery: a prospective, randomized controlled non-inferiority trial
Sign Up to like & getrecommendations! Published in 2017 at "European Spine Journal"
DOI: 10.1007/s00586-017-5213-5
Abstract: PurposeTo compare the efficacy of a transdermal buprenorphine patch (5, 10, 15, and 20 μg/h) with that of oral tramadol (150, 200, 250, and 300 mg) for postoperative pain control after single level spinal fusion surgery.MethodsThe present… read more here.
Keywords: buprenorphine; efficacy; postoperative pain; fusion surgery ... See more keywords
Pharmacokinetic Evaluation of Once-Weekly and Once-Monthly Buprenorphine Subcutaneous Injection Depots (CAM2038) Versus Intravenous and Sublingual Buprenorphine in Healthy Volunteers Under Naltrexone Blockade: An Open-Label Phase 1 Study
Sign Up to like & getrecommendations! Published in 2017 at "Advances in Therapy"
DOI: 10.1007/s12325-016-0472-9
Abstract: AbstractIntroductionCAM2038 q1w (once weekly) and q4w (once monthly) are investigational buprenorphine subcutaneous (SC) formulations based on FluidCrystal® injection depot technology. These two drug products are being developed for opioid dependence treatment, with a target for… read more here.
Keywords: treatment; cam2038 q1w; sublingual buprenorphine; cam2038 ... See more keywords