In vitro to in vivo extrapolation of the complex drug‐drug interaction of bupropion and its metabolites with CYP2D6; simultaneous reversible inhibition and CYP2D6 downregulation
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DOI: 10.1016/j.bcp.2016.11.007
Abstract: Graphical abstract Figure. No Caption available. Abstract Bupropion is a widely used antidepressant and smoking cessation aid and a strong inhibitor of CYP2D6 in vivo. Bupropion is administered as a racemic mixture of R‐ and… read more here.
Keywords: cyp2d6; drug; bupropion metabolites; reversible inhibition ... See more keywords