Rare variant association testing for multicategory phenotype
Sign Up to like & getrecommendations! Published in 2019 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22210
Abstract: Genetic association studies have provided new insights into the genetic variability of human complex traits with a focus mainly on continuous or binary traits. Methods have been proposed to take into account disease heterogeneity between… read more here.
Keywords: association testing; association; burden tests; rare variants ... See more keywords
Burden tests can be used to map causal genes for a simple metabolic trait in an exome‐sequenced polyploid mutant population
Sign Up to like & getrecommendations! Published in 2022 at "Plant Biotechnology Journal"
DOI: 10.1111/pbi.13890
Abstract: genetic screens are excellent tool to assign gene function, but it is often necessary to employ map-based cloning to identify the causal genes. This can be laborious and represents a bottleneck in in DNA it… read more here.
Keywords: burden tests; causal genes; exome sequenced; mutant population ... See more keywords