Protein with negative surface charge distribution, Bnr1, shows characteristics of a DNA‐mimic protein and may be involved in the adaptation of Burkholderia cenocepacia
Sign Up to like & getrecommendations! Published in 2022 at "MicrobiologyOpen"
DOI: 10.1002/mbo3.1264
Abstract: Adaptation of opportunistic pathogens to their host environment requires reprogramming of a vast array of genes to facilitate survival in the host. Burkholderia cenocepacia, a Gram‐negative bacterium with a large genome of ∼8 Mb that colonizes… read more here.
Keywords: burkholderia cenocepacia; adaptation; surface charge; bcas0292 ... See more keywords
Burkholderia cenocepacia utilizes a type VI secretion system for bacterial competition
Sign Up to like & getrecommendations! Published in 2019 at "MicrobiologyOpen"
DOI: 10.1002/mbo3.774
Abstract: Burkholderia cenocepacia is an opportunistic bacterial pathogen that poses a significant threat to individuals with cystic fibrosis by provoking a strong inflammatory response within the lung. It possesses a type VI secretion system (T6SS), a… read more here.
Keywords: cenocepacia; system; burkholderia cenocepacia; t6ss ... See more keywords
Synthesis of a trisaccharide repeating unit of the O-antigen from Burkholderia cenocepacia and its dimer.
Sign Up to like & getrecommendations! Published in 2017 at "Carbohydrate research"
DOI: 10.1016/j.carres.2017.09.001
Abstract: The trisaccharide repeating unit of an O-antigen derived from Burkholderia cenocepacia and its dimer, i.e., α-L-Rhap-(1 → 3)-α-D-GalpNAc-(1 → 3)-β-D-GalpNAc-O(CH2)3N3 (1) and α-L-Rhap-(1 → 3)-α-D-GalpNAc-(1 → 3)-β-D-GalpNAc-(1 → 4)-α-L-Rhap-(1 → 3)-α-D-GalpNAc-(1 → 3)-β-D-GalpNAc-O(CH2)3N3 (2), respectively, were synthesized via a highly convergent strategy. Glycosylation of galactosaminyl acceptor 4 with galactosaminyl… read more here.
Keywords: burkholderia cenocepacia; trisaccharide repeating; repeating unit; unit antigen ... See more keywords
Inactivation of Rho GTPases by Burkholderia cenocepacia Induces a WASH-Mediated Actin Polymerization that Delays Phagosome Maturation
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107721
Abstract: SUMMARY Burkholderia cenocepacia is an opportunistic bacterial pathogen that causes severe pulmonary infections in cystic fibrosis and chronic granulomatous disease patients. B. cenocepacia can survive inside infected macrophages within the B. cenocepacia-containing vacuole (BcCV) and… read more here.
Keywords: inactivation rho; rho gtpases; cenocepacia induces; burkholderia cenocepacia ... See more keywords
Targeting a Multidrug-Resistant Pathogen: First Generation Antagonists of Burkholderia cenocepacia’s BC2L-C Lectin
Sign Up to like & getrecommendations! Published in 2022 at "ACS Chemical Biology"
DOI: 10.1021/acschembio.2c00532
Abstract: Multidrug-resistant pathogens such as Burkholderia cenocepacia have become a hazard in the context of healthcare-associated infections, especially for patients admitted with cystic fibrosis or immuno-compromising conditions. Like other opportunistic Gram-negative bacteria, this pathogen establishes virulence… read more here.
Keywords: burkholderia cenocepacia; lectin; targeting multidrug; bc2l ... See more keywords
Mouse intestinal niche cells express a distinct &agr;1,2-fucosylated glycan recognized by a lectin from Burkholderia cenocepacia
Sign Up to like & getrecommendations! Published in 2017 at "Glycobiology"
DOI: 10.1093/glycob/cww116
Abstract: In this study, we examined the distribution of fucosylated glycans in mouse intestines using a lectin, BC2LCN (N-terminal domain of the lectin BC2L-C from Burkholderia cenocepacia), as a probe. BC2LCN is specific for glycans with… read more here.
Keywords: burkholderia cenocepacia; intestinal niche; lectin; niche ... See more keywords
The Burkholderia cenocepacia iron starvation σ factor, OrbS, possesses an on-board iron sensor
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac137
Abstract: Abstract Burkholderia cenocepacia is an opportunistic pathogen that causes severe infections of the cystic fibrosis (CF) lung. To acquire iron, B. cenocepacia secretes the Fe(III)-binding compound, ornibactin. Genes for synthesis and utilisation of ornibactin are… read more here.
Keywords: burkholderia cenocepacia; iron; cenocepacia; factor orbs ... See more keywords
Comparative analysis of the Burkholderia cenocepacia K56-2 essential genome reveals cell envelope functions that are uniquely required for survival in species of the genus Burkholderia
Sign Up to like & getrecommendations! Published in 2017 at "Microbial Genomics"
DOI: 10.1099/mgen.0.000140
Abstract: Burkholderia cenocepacia K56-2 belongs to the Burkholderia cepacia complex, a group of Gram-negative opportunistic pathogens that have large and dynamic genomes. In this work, we identified the essential genome of B. cenocepacia K56-2 using high-density… read more here.
Keywords: essential genome; cenocepacia; cenocepacia k56; burkholderia cenocepacia ... See more keywords
High intracellular c-di-GMP levels antagonize quorum sensing and virulence gene expression in Burkholderia cenocepacia H111.
Sign Up to like & getrecommendations! Published in 2017 at "Microbiology"
DOI: 10.1099/mic.0.000452
Abstract: The opportunistic human pathogen Burkholderia cenocepacia H111 uses two chemically distinct signal molecules for controlling gene expression in a cell density-dependent manner: N-acyl-homoserine lactones (AHLs) and cis-2-dodecenoic acid (BDSF). Binding of BDSF to its cognate… read more here.
Keywords: burkholderia cenocepacia; virulence; gmp; cenocepacia h111 ... See more keywords
Small RNA NcS27 co-regulates utilization of carbon sources in Burkholderia cenocepacia J2315.
Sign Up to like & getrecommendations! Published in 2019 at "Microbiology"
DOI: 10.1099/mic.0.000848
Abstract: Small non-coding sRNAs have versatile roles in regulating bacterial metabolism. Four short homologous Burkholderia cenocepacia sRNAs strongly expressed under conditions of growth arrest were recently identified. Here we report the detailed investigation of one of… read more here.
Keywords: small rna; burkholderia cenocepacia; rna ncs27; ncs27 ... See more keywords
The anti-virulence activity of the non-mevalonate pathway inhibitor FR900098 towards Burkholderia cenocepacia is maintained during experimental evolution.
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology"
DOI: 10.1099/mic.0.001170
Abstract: Burkholderia cenocepacia infections are difficult to treat and there is an urgent need for alternative (combination) treatments. The use of anti-virulence therapies in combination with antibiotics is a possible strategy to increase the antimicrobial susceptibility… read more here.
Keywords: burkholderia cenocepacia; fr900098; activity; anti virulence ... See more keywords