Burn-induced muscle metabolic derangements and mitochondrial dysfunction are associated with activation of HIF-1α and mTORC1: Role of protein farnesylation
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DOI: 10.1038/s41598-017-07011-3
Abstract: Metabolic derangements are a clinically significant complication of major trauma (e.g., burn injury) and include various aspects of metabolism, such as insulin resistance, muscle wasting, mitochondrial dysfunction and hyperlactatemia. Nonetheless, the molecular pathogenesis and the… read more here.
Keywords: protein farnesylation; muscle; dysfunction; burn induced ... See more keywords
Burn Induced Apoptosis of Pulmonary Microvascular Endothelial Cell is NHE1 Dependent and Regulated by PI3K-Akt and p38 MAPK Pathways.
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DOI: 10.1097/shk.0000000000001573
Abstract: Na/H exchanger 1 (NHE1) is a ubiquitously expressed protein on mammalian plasma membranes and involved in cell apoptosis and tissue injury. Our previous study found that NHE1 inhibition prevents burn-induced acute lung injury (ALI). However,… read more here.
Keywords: cell apoptosis; burn induced; p38 mapk; apoptosis ... See more keywords
Human Umbilical Cord Mesenchymal Stem Cells Attenuate Severe Burn-Induced Multiple Organ Injury via Potentiating IGF-1 and BCL-2/BAX Pathway
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DOI: 10.1155/2022/5474289
Abstract: Background Early multiple organ injuries induced by severe burn predict a high mortality. Mesenchymal stem cells (MSCs) are able to repair and reconstruct the injured tissues and organs induced by trauma and diseases. However, potential… read more here.
Keywords: burn; severe burn; hucmscs; burn induced ... See more keywords
Use of Autologous Serum Eye Drops with Contact Lenses in the Treatment of Chemical Burn-Induced Bilateral Corneal Persistent Epithelial Defects
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DOI: 10.1155/2022/6600788
Abstract: Objective We aim to evaluate the clinical effect of combined topical 20% autologous serum eye drops (ASEs) along with silicone–hydrogel soft contact lenses (SCLs) in the treatment of chemical burn-induced bilateral corneal persistent epithelial defects… read more here.
Keywords: bilateral corneal; corneal; burn induced; chemical burn ... See more keywords
Abstract 232: PDE5A Inhibition in Burn-induced Cardiac Dysfunction
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DOI: 10.1161/res.127.suppl_1.232
Abstract: Severe burn injury initiates a feedback cycle of inflammation, fibrosis and oxidative stress and others that may contribute to heart dysfunction via the PDE5A-cGMP-PKG pathway. Sildenafil (SIL) has been shown decrease immune adverse events in… read more here.
Keywords: pde5a; burn; heart; dysfunction ... See more keywords
Burn-Induced Acute Kidney Injury–Two-Lane Road: From Molecular to Clinical Aspects
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DOI: 10.3390/ijms23158712
Abstract: Severe burn injuries lead to acute kidney injury (AKI) development, increasing the mortality risk up to 28–100%. In addition, there is an increase in hospitalization days and complications appearance. Various factors are responsible for acute… read more here.
Keywords: acute kidney; kidney; kidney injury; induced acute ... See more keywords
Bee venom reduces burn-induced pain via the suppression of peripheral and central substance P expression in mice
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DOI: 10.4142/jvs.2021.22.e9
Abstract: Background Scalding burn injuries can occur in everyday life but occur more frequently in young children. Therefore, it is important to develop more effective burn treatments. Objectives This study examined the effects of bee venom… read more here.
Keywords: induced pain; peripheral central; expression; bee venom ... See more keywords