In situ forming PLGA implant for 90 days controlled release of leuprolide acetate for treatment of prostate cancer
Sign Up to like & getrecommendations! Published in 2017 at "Polymers for Advanced Technologies"
DOI: 10.1002/pat.3991
Abstract: In prostate cancer, hormone therapy via leuprolide acetate drug (LUP) is used to lower the level of testosterone down to castration level to effectively control the development of prostate cancer. The objective of this study… read more here.
Keywords: degradation; leuprolide acetate; burst release; prostate cancer ... See more keywords
Composite material consisting of microporous β-TCP ceramic and alginate for delayed release of antibiotics.
Sign Up to like & getrecommendations! Published in 2017 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2017.01.045
Abstract: OBJECTIVE The aim of this study was to produce a novel composite of microporous β-TCP filled with alginate and Vancomycin (VAN) to prolong the release behavior of the antibiotic for up to 28days. MATERIAL AND… read more here.
Keywords: alginate; composite material; burst release; release ... See more keywords
Modeling of the burst release from PLGA micro- and nanoparticles as function of physicochemical parameters and formulation characteristics.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.08.118
Abstract: A substantial drug release from poly(lactic-co-glycolic) acid (PLGA) micro- and nanoparticles can occur in the first hours of immersion, which is referred to as burst release. A strong burst release (when not intentional) is to… read more here.
Keywords: micro nanoparticles; burst release; drug; plga micro ... See more keywords
Hierarchically structured phase separated biopolymer hydrogels create tailorable delayed burst release during gastrointestinal digestion.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of colloid and interface science"
DOI: 10.1016/j.jcis.2019.06.033
Abstract: The on demand delivery of novel peptide actives, traditional pharmaceuticals, nutrients and/or vitamins is a ever present challenge due to the digestive and metabolic degradation of the active and the delivery vehicle. Biodegradable biopolymer hydrogels… read more here.
Keywords: burst release; biopolymer; delivery; release ... See more keywords
A novel pellets/thermosensitive hydrogel depot with low burst release for long-term continuous drug release: Preparation, characterization, in vitro and in vivo studies
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2020.102050
Abstract: Abstract The purpose of this study was to develop a pellets/thermosensitive gel hybrid depot (Pellets-Gel), designed to provide a novel implant delivery system for long-term steady controlled release of poor soluble drug with less burst… read more here.
Keywords: pellets thermosensitive; cur pellets; burst release; drug ... See more keywords
3D-Printed Wearable Personalized Orthodontic Retainers for Sustained Release of Clonidine Hydrochloride
Sign Up to like & getrecommendations! Published in 2019 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-019-1460-6
Abstract: Orthodontic retainers are wearable customizable medical devices for dental protection or alignment. Here, clonidine hydrochloride (CH)-loaded wearable personalized 3D printed orthodontic retainers were studied for local sustained-release of drugs. CH powders were mixed with PEG… read more here.
Keywords: burst release; retainer; sustained release; wearable personalized ... See more keywords
Cell-mimicking polyethylene glycol-diacrylate based nanolipogel for encapsulation and delivery of hydrophilic biomolecule
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2023.1113236
Abstract: Lipid based nanoparticulate formulations have been widely used for the encapsulation and sustain release of hydrophilic drugs, but they still face challenges such as high initial burst release. Nanolipogel (NLG) emerges as a potential system… read more here.
Keywords: initial burst; encapsulation; burst release; release ... See more keywords