A Mechanochemical Model of Transcriptional Bursting.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical journal"
DOI: 10.1016/j.bpj.2020.01.017
Abstract: Populations of genetically identical cells generally show a large variability in cell phenotypes, which is typically associated with the stochastic nature of gene expression processes. It is widely believed that a significant source of such… read more here.
Keywords: transcription; bursting; transcriptional bursting; model transcriptional ... See more keywords
Canonical models for torus canards in elliptic bursters.
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DOI: 10.1063/5.0037204
Abstract: We revisit elliptic bursting dynamics from the viewpoint of torus canard solutions. We show that at the transition to and from elliptic burstings, classical or mixed-type torus canards may appear, the difference between the two… read more here.
Keywords: elliptic bursting; bursting; elliptic bursters; mixed type ... See more keywords
BISC: accurate inference of transcriptional bursting kinetics from single-cell transcriptomic data
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac464
Abstract: Gene expression in mammalian cells is inherently stochastic and mRNAs are synthesized in discrete bursts. Single-cell transcriptomics provides an unprecedented opportunity to explore the transcriptome-wide kinetics of transcriptional bursting. However, current analysis methods provide limited… read more here.
Keywords: bursting; cell; bisc; cell transcriptomic ... See more keywords
Inferring transcriptional bursting kinetics from single-cell snapshot data using a generalized telegraph model
Sign Up to like & getrecommendations! Published in 2022 at "Royal Society Open Science"
DOI: 10.1098/rsos.221057
Abstract: Motivation Gene expression has inherent stochasticity resulting from transcription’s burst manners. Single-cell snapshot data can be exploited to rigorously infer transcriptional burst kinetics, using mathematical models as blueprints. The classical telegraph model (CTM) has been… read more here.
Keywords: bursting; cell snapshot; transcriptional bursting; burst ... See more keywords
3 ′-5 ′ crosstalk contributes to transcriptional bursting
Sign Up to like & getrecommendations! Published in 2021 at "Genome Biology"
DOI: 10.1186/s13059-020-02227-5
Abstract: Background Transcription in mammalian cells is a complex stochastic process involving shuttling of polymerase between genes and phase-separated liquid condensates. It occurs in bursts, which results in vastly different numbers of an mRNA species in… read more here.
Keywords: bursting; crosstalk contributes; transcriptional bursting; contributes transcriptional ... See more keywords