Thiotepa, busulfan and fludarabine compared to busulfan and cyclophosphamide as conditioning regimen for allogeneic stem cell transplant from matched siblings and unrelated donors for acute myeloid leukemia
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DOI: 10.1002/ajh.25225
Abstract: Busulfan plus cyclophosphamide (BuCy) is the traditional conditioning regimen for allogeneic stem cell transplant (allo‐SCT) for young, fit patients with acute myeloid leukemia (AML). The thiotepa‐busulfan‐fludarabine (TBF) protocol has recently demonstrated promising outcome in cord… read more here.
Keywords: busulfan; regimen allogeneic; transplant; conditioning regimen ... See more keywords
Utilization of a population pharmacokinetic model to improve a busulfan test-dose strategy in allogeneic hematopoietic cell transplant recipients.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of clinical pharmacology"
DOI: 10.1002/jcph.2257
Abstract: Busulfan is an alkylating agent used as part of conditioning chemotherapy regimens prior to allogeneic hematopoietic cell transplant (allo-HCT). Pharmacokinetic (PK)-guided test-dose strategies have been shown to improve the number of patients achieving busulfan exposure… read more here.
Keywords: strategy; busulfan; model; test dose ... See more keywords
Intravenous busulfan plus melphalan versus melphalan alone as conditioning regimen for patients with multiple myeloma
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DOI: 10.1007/s00277-019-03663-5
Abstract: Dear Editor, To improve results in transplant-eligible multiple myeloma (MM) patients, the combination of busulfan and melphalan (BUMEL) has been used as an alternative conditioning regimen to standard-dose melphalan 200 mg/m (MEL200) [1–4]. The results… read more here.
Keywords: busulfan; bumel; control; multiple myeloma ... See more keywords
Thiotepa, busulfan, and cyclophosphamide or busulfan, cyclophosphamide, and etoposide high-dose chemotherapy followed by autologous stem cell transplantation for consolidation of primary central nervous system lymphoma
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Hematology"
DOI: 10.1007/s00277-019-03667-1
Abstract: Primary central nervous system lymphoma (PCNSL) is a rare extranodal non-Hodgkin lymphoma for which standard treatment has yet to be established. High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is a suitable consolidation strategy… read more here.
Keywords: chemotherapy; busulfan; consolidation; primary central ... See more keywords
Busulfan-cyclophosphamide versus cyclophosphamide-busulfan as conditioning regimen before allogeneic hematopoietic cell transplantation: a prospective randomized trial
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Hematology"
DOI: 10.1007/s00277-020-04312-y
Abstract: Busulfan and cyclophosphamide (BuCy) is a frequently used myeloablative conditioning regimen for allogeneic hematopoietic cell transplantation (allo-HCT). Theoretical considerations and pharmacological data indicate that application of busulfan prior to subsequent cyclophosphamide (BuCy) may trigger liver… read more here.
Keywords: busulfan; regimen allogeneic; allogeneic hematopoietic; conditioning regimen ... See more keywords
Limited sampling strategy for predicting busulfan exposure in hematopoietic stem cell transplantation recipients
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DOI: 10.1007/s11096-017-0481-z
Abstract: Background Optimization of the area under the concentration–time curve (AUC) of busulfan, an essential component of conditioning regimens, improves the outcomes in patients undergoing hematopoietic stem cell transplantation (HSCT). Traditional sampling methods for calculating AUC… read more here.
Keywords: busulfan; cell transplantation; limited sampling; stem cell ... See more keywords
Oral levetiracetam for prevention of busulfan-induced seizures in adult hematopoietic cell transplant
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DOI: 10.1007/s11096-020-00977-7
Abstract: Background Antiseizure prophylaxis is recommended when high-dose of busulfan is given as part of the conditioning regimens in the allogenic hematopoietic stem cell transplant. Phenytoin has been widely used but its pharmacokinetics and pharmacodynamics profile… read more here.
Keywords: busulfan; oral levetiracetam; levetiracetam; prevention busulfan ... See more keywords
Late Effects Following Hematopoietic Stem Cell Transplant with Busulfan-Based Preparative Regimen in Fanconi Anemia
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DOI: 10.1016/j.bbmt.2018.12.155
Abstract: Introduction Outcomes of hematopoietic stem cell transplant (HSCT) in Fanconi Anemia (FA) have markedly improved with use of low dose cyclophosphamide and fludarabine and the advent of T-cell depleted donor grafts. Most recently, use of… read more here.
Keywords: anemia; transplant; preparative regimen; busulfan ... See more keywords
Comparative effectiveness of busulfan/cyclophosphamide versus busulfan/fludarabine myeloablative conditioning for allogeneic hematopoietic cell transplantation in acute myeloid leukemia and myelodysplastic syndrome.
Sign Up to like & getrecommendations! Published in 2019 at "Hematology/oncology and stem cell therapy"
DOI: 10.1016/j.hemonc.2019.09.002
Abstract: OBJECTIVE/BACKGROUND Busulfan/cyclophosphamide (Bu/Cy) and busulfan/fludarabine (Bu/Flu) are both standard myeloablative conditioning (MAC) regimens for allogeneic hematopoietic cell transplantation (alloHCT). We compared the effectiveness of these regimens with a focus on quality of life (QOL). METHODS… read more here.
Keywords: busulfan; cell; busulfan fludarabine; allogeneic hematopoietic ... See more keywords
Development and characterization of an organic solvent free, proliposomal formulation of Busulfan using quality by design approach.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.11.007
Abstract: Parenteral administration of Busulfan (BU) conquers the bioavailability and biovariability related issues of oral BU by maintaining the plasma drug concentration in therapeutic range with minimal fluctuations thereby significantly reducing the side effects. Busulfex® is… read more here.
Keywords: busulfan; design; proliposomal formulation; formulation ... See more keywords
Fast and reliable quantification of busulfan in blood plasma using two-channel liquid chromatography tandem mass spectrometry: Validation of assay performance in the presence of drug formulation excipients.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2021.114216
Abstract: A fast and reliable method based on two-channel liquid chromatography coupled to tandem mass spectrometry was developed and successfully validated for quantification of busulfan. The drug vehicle polyethylene glycol 400 was quantified simultaneously in patient… read more here.
Keywords: busulfan; assay performance; mass; drug ... See more keywords