Stereodivergent synthesis of 2-alkynyl buta-1,3-dienes using Sonogashira coupling with controllable retention or inversion of olefin geometry
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DOI: 10.1016/j.tetlet.2019.151565
Abstract: Abstract A stereodivergent approach to 2-alkynyl buta-1,3-dienes from a single stereoisomer of starting α-bromoenal has been developed. By simply switching the sequence of Sonogashira and Horner-Wadsworth-Emmons reactions, it is possible to obtain these branched dienynes… read more here.
Keywords: alkynyl buta; retention; geometry; buta dienes ... See more keywords
Synthesis of silylbut-1-en-3-ynes and buta-1,3-dienes as building blocks via hydrosilylation of 1,4-bis(trimethylsilyl)buta-1,3-diyne
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DOI: 10.1038/s41598-024-82198-w
Abstract: The selective and efficient synthesis of (E)-1,2,4-trisilylbut-1-en-3-ynes obtained via Pt-catalyzed hydrosilylation of 1,4-bis(trimethylsilyl)buta-1,3-diyne is described. Optimized reaction conditions (Pt(PPh3)4) or Pt2(dvs)3, 100 °C, toluene, 18 h) yielded compounds with high isolation yields (76–95%). The modification… read more here.
Keywords: buta dienes; hydrosilylation bis; trimethylsilyl buta; buta diyne ... See more keywords
Assembly of Diverse 3-Methylenetetrahydrofurans via Palladium-Catalyzed Cascade Carboetherification of Buta-1,3-Dienes with Alkynols
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DOI: 10.3390/molecules30214244
Abstract: Tetrahydrofuran scaffolds have found promising applications in both pharmaceutical chemistry and organic synthesis but remain underexplored owing to the challenges associated with their preparation. Herein, we have developed a robust synthetic strategy for the palladium-catalyzed… read more here.
Keywords: buta dienes; palladium catalyzed; diverse methylenetetrahydrofurans; assembly diverse ... See more keywords