Butein induction of HO‐1 by p38 MAPK/Nrf2 pathway in adipocytes attenuates high‐fat diet induced adipose hypertrophy in mice
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.02.021
Abstract: Abstract Adipose tissue inflammation and oxidative stress are key components in the development of obesity and insulin resistance. Heme oxygenase (HO)−1 in adipocytes protects against obesity and adipose dysfunction. In this study, we report the… read more here.
Keywords: p38 mapk; fat diet; high fat; butein ... See more keywords
Butein inhibits IL‐1&bgr;‐induced inflammatory response in human osteoarthritis chondrocytes and slows the progression of osteoarthritis in mice
Sign Up to like & getrecommendations! Published in 2017 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2016.11.009
Abstract: Abstract Osteoarthritis (OA) is a progressive degenerative disease characterized by irreversible articular cartilage destruction. Butein, a polyphenolic compound isolated from the stem bark of cashews and Rhus verniciflua Stokes, has been reported to have anti‐inflammatory… read more here.
Keywords: osteoarthritis; mmp; human osteoarthritis; bgr induced ... See more keywords
Butein inhibits adipocyte differentiation by modulating the AMPK pathway in 3T3‐L1 cells
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DOI: 10.1111/jfbc.12441
Abstract: Butein (3,4,2ʹ,4ʹ-tetrahydroxychalcone), a chalcone derivative, has been reported to exhibit various biological effects. However, the inhibitory effects of butein on adipocyte differentiation mediated via the adenosine 5ʹ-monophosphate-activated protein kinase (AMPK) signaling pathway have not been… read more here.
Keywords: adipocyte differentiation; pathway 3t3; butein; 3t3 cells ... See more keywords
Butein Ameliorates Oxidative Stress in H9c2 Cardiomyoblasts through Activation of the NRF2 Signaling Pathway
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DOI: 10.3390/antiox11081430
Abstract: Oxidative stress, defined as an imbalance between reactive oxygen species (ROS) production and the antioxidant defense system, contributes to the pathogenesis of many heart diseases. Therefore, oxidative stress has been highlighted as a therapeutic target… read more here.
Keywords: stress; oxidative stress; h9c2 cardiomyoblasts; ros production ... See more keywords