Melatonin is an effective protector of gingival cells damaged by the cytotoxic effect of glutamate and DL-buthionine sulfoximine.
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DOI: 10.1111/jre.12806
Abstract: BACKGROUND AND OBJECTIVE Cellular damage related to oxidative stress (OS) is implicated in periodontal diseases (PD). Melatonin (MEL) has multiple functions, and it has been described as a potential treatment for PD. We aim at… read more here.
Keywords: buthionine sulfoximine; gcs; mel; gingival cells ... See more keywords
Abstract 539: Buthionine Sulfoximine (BSO) Prevents Reductive Stress-induced Pathological Hypertrophic Cardiomyopathy
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DOI: 10.1161/res.127.suppl_1.539
Abstract: Background: Chronic reductive stress (RS) induces pathological cardiac remodeling and diastolic dysfunction. Here, we hypothesized that preventing RS via glutathione (GSH) depletion, through selective inhibition of γ-glutamyl cysteine ligase (γGCL), mitigates cardiac pathology in cRS… read more here.
Keywords: bso; gsh; reductive stress; sulfoximine bso ... See more keywords
Polyurea Dendrimer Folate-Targeted Nanodelivery of l-Buthionine Sulfoximine as a Tool to Tackle Ovarian Cancer Chemoresistance
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DOI: 10.3390/antiox9020133
Abstract: Ovarian cancer is a highly lethal disease, mainly due to chemoresistance. Our previous studies on metabolic remodeling in ovarian cancer have supported that the reliance on glutathione (GSH) bioavailability is a main adaptive metabolic mechanism,… read more here.
Keywords: chemoresistance; folate; ovarian cancer; cancer ... See more keywords