The Natural Product Butylcycloheptyl Prodiginine Binds Pre-miR-21, Inhibits Dicer-Mediated Processing of Pre-miR-21, and Blocks Cellular Proliferation.
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DOI: 10.1016/j.chembiol.2019.04.011
Abstract: Identification of RNA-interacting pharmacophores could provide chemical probes and, potentially, small molecules for RNA-based therapeutics. Using a high-throughput differential scanning fluorimetry assay, we identified small-molecule natural products with the capacity to bind the discrete stem-looped… read more here.
Keywords: butylcycloheptyl prodiginine; dicer mediated; pre mir; mir ... See more keywords