Structural Insight of New Butyrylcholinesterase Inhibitors Based on Benzylbenzofuran Scaffold
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DOI: 10.3390/ph15030304
Abstract: In the present work, we use a merger of computational and biochemical techniques as a rational guideline for structural modification of benzofuran derivatives to find pertinent structural features for the butyrylcholinesterase inhibitory activity and selectivity.… read more here.
Keywords: inhibitors based; structural insight; butyrylcholinesterase inhibitors; new butyrylcholinesterase ... See more keywords
Identification of sulfonamide-based butyrylcholinesterase inhibitors using machine learning.
Sign Up to like & getrecommendations! Published in 2022 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2021-0325
Abstract: Aim: This study reports the designing of BChE inhibitors through machine learning (ML), followed by in silico and in vitro evaluations. Methodology: ML technique was used to predict the virtual hit, and its derivatives were synthesized… read more here.
Keywords: machine; machine learning; butyrylcholinesterase inhibitors; based butyrylcholinesterase ... See more keywords