Arglabin regulates microglia polarization to relieve neuroinflammation in Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23045
Abstract: Arglabin (Arg) is a derivative of parthenolide. At present, there are few reports on the pharmacological effects and targets of Arg. In this study, we aimed to explore the relationship between Arg and NF-κB (P50)… read more here.
Keywords: expression; p50 p50; polarization; bv2 cells ... See more keywords
Panaxatriol Saponins Promote M2 Polarization of BV2 Cells to Reduce Inflammation and Apoptosis after Glucose/Oxygen Deprivation by Activating STAT3
Sign Up to like & getrecommendations! Published in 2020 at "Inflammation"
DOI: 10.1007/s10753-020-01278-x
Abstract: Panaxatriol saponins (PTS) have a long history in the treatment of stroke. In our previous experiments, PTS has been found to alleviate ischemic stroke and play a role through regulating the inflammatory response, but the… read more here.
Keywords: promote polarization; apoptosis; inflammation; polarization ... See more keywords
The isothiocyanate sulforaphane prevents mitochondrial impairment and neuroinflammation in the human dopaminergic SH-SY5Y and in the mouse microglial BV2 cells: role for heme oxygenase-1.
Sign Up to like & getrecommendations! Published in 2022 at "Metabolic brain disease"
DOI: 10.1007/s11011-022-00990-x
Abstract: Sulforaphane (SFN) promotes protective effects in different cell types. Nonetheless, it remains to be clarified by which mechanism SFN exerts benefits in mammalian cells. Mitochondria are a major source of adenosine triphosphate (ATP) and reactive… read more here.
Keywords: sfn; bv2 cells; mitochondrial impairment; heme oxygenase ... See more keywords
Persistent Acidic Environment Induces Impaired Phagocytosis via ERK in Microglia.
Sign Up to like & getrecommendations! Published in 2022 at "Neurochemical research"
DOI: 10.1007/s11064-022-03533-z
Abstract: Acidic environment evoked by stroke, traumatic brain injury, and Alzheimer's disease may change the functional properties of microglia. Nevertheless, the underlying mechanisms of functional changes in microglia remain unclear. In this study, we found that… read more here.
Keywords: environment induces; acidic environment; environment; erk ... See more keywords
HIV-1 gp120 Upregulates Brain-Derived Neurotrophic Factor (BDNF) Expression in BV2 Cells via the Wnt/β-Catenin Signaling Pathway
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-017-0931-z
Abstract: HIV-1 gp120 plays a critical role in the pathogenesis of HIV-associated pain, but the underlying molecular mechanisms are incompletely understood. This study aims to determine the effect and possible mechanism of HIV-1 gp120 on BDNF… read more here.
Keywords: catenin; gp120; bv2 cells; bdnf expression ... See more keywords
In vitro examination of microglia-neuron crosstalk with BV2 cells, and primary cultures of glia and hypothalamic neurons
Sign Up to like & getrecommendations! Published in 2018 at "Heliyon"
DOI: 10.1016/j.heliyon.2018.e00730
Abstract: Microglia respond to environmental changes by releasing cytokines that beneficially or detrimentally affect surrounding cells in addition to functioning as the resident CNS macrophages. Interactions between glia and neurons participate in many critical brain functions… read more here.
Keywords: hypothalamic neurons; microglia; cultures glia; primary cultures ... See more keywords
A synthetic diosgenin primary amine derivative attenuates LPS‐stimulated inflammation via inhibition of NF‐&kgr;B and JNK MAPK signaling in microglial BV2 cells
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2018.05.021
Abstract: &NA; Diosgenin, a precursor of steroid hormones in plants, is known to exhibit diverse pharmacological activities including anti‐inflammatory properties. In this study, (3&bgr;, 25R)‐spirost‐5‐en‐3‐oxyl (2‐((2((2‐aminoethyl)amino)ethyl)amino)ethyl) carbamate (DGP), a new synthetic diosgenin derivative incorporating primary amine… read more here.
Keywords: jnk; lps stimulated; diosgenin; bv2 cells ... See more keywords
Endoplasmic reticulum stress manipulates autophagic response that antagonizes polybrominated diphenyl ethers quinone induced cytotoxicity in microglial BV2 cells.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2020.124958
Abstract: Polybrominated diphenyl ethers (PBDEs) were widely used as flame retardants. Previously, we reported that their quinone-type metabolite (PBDEQ) induced selective autophagy, but its biological consequences remain obscure. Here, we illustrated the possible link of PBDEQ-induced… read more here.
Keywords: pbdeq; stress; pbdeq induced; bv2 cells ... See more keywords
Effects of hypnotic bromovalerylurea on microglial BV2 cells.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2017.05.007
Abstract: An old sedative and hypnotic bromovalerylurea (BU) has anti-inflammatory effects. BU suppressed nitric oxide (NO) release and proinflammatory cytokine expression by lipopolysaccharide (LPS)-treated BV2 cells, a murine microglial cell line. However, BU did not inhibit… read more here.
Keywords: lps induced; hypnotic bromovalerylurea; stat1; expression ... See more keywords
Capillarisin augments anti-oxidative and anti-inflammatory responses by activating Nrf2/HO-1 signaling
Sign Up to like & getrecommendations! Published in 2017 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2017.01.018
Abstract: Abstract Capillarisin is a naturally isolated chromone, which is one of the major bioactive constituents of Artemisia capillaries. Capillarisin has antioxidant, anti‐inflammatory, and anti‐tumor potential, but the underlying molecular mechanisms remain largely unclear. In the… read more here.
Keywords: anti inflammatory; capillarisin; inflammatory responses; nrf2 signaling ... See more keywords
Macluraxanthone B inhibits LPS-induced inflammatory responses in RAW264.7 and BV2 cells by regulating the NF-κB and MAPK signaling pathways.
Sign Up to like & getrecommendations! Published in 2021 at "Immunopharmacology and immunotoxicology"
DOI: 10.1080/08923973.2021.2006215
Abstract: OBJECTIVE The prenylated xanthones compounds, macluraxanthone B (MCXB) was isolated from the MeOH extracts of Cudrania tricuspidata. In this study, we investigated the effect of MCXB on inflammatory response. MATERIALS AND METHODS Anti-inflammatory effects of… read more here.
Keywords: anti inflammatory; lps induced; raw264 bv2; mcxb ... See more keywords