Biliverdin reductase deficiency triggers an endothelial-to-mesenchymal transition in human endothelial cells.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2019.108182
Abstract: Endothelial dysfunction accompanied by the loss of endothelial cell phenotype plays an essential role in cardiovascular diseases. Here, we report that inhibition of biliverdin reductase (BVR), the enzyme of the heme degradation pathway converting biliverdin… read more here.
Keywords: mesenchymal transition; endothelial mesenchymal; biliverdin reductase; endothelial cells ... See more keywords
The brain heme oxygenase/biliverdin reductase system as a target in drug research and development
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2022.2052848
Abstract: ABSTRACT Introduction The heme oxygenase/biliverdin reductase (HO/BVR) system is involved in heme metabolism. The inducible isoform of HO (HO-1) and BVR both exert cytoprotective effects by enhancing cell stress response. In this context, some xenobiotics,… read more here.
Keywords: system; research; oxygenase biliverdin; heme oxygenase ... See more keywords