Tumor neoantigen heterogeneity impacts bystander immune inhibition of pancreatic cancer growth
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DOI: 10.1016/j.tranon.2020.100856
Abstract: The immunogenic clonal-fraction threshold in heterogeneous solid-tumor required to induce effective bystander-killing of non-immunogenic subclones is unknown. Pancreatic cancer poses crucial challenges for immune therapeutic interventions due to low mutational-burden and consequent lack of neoantigens.… read more here.
Keywords: neoantigen; pancreatic cancer; cancer; growth ... See more keywords