The Promise study: A presurgical randomized clinical trial of CE/BZA vs placebo in postmenopausal women with ductal carcinoma in situ.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.16_suppl.512
Abstract: 512 Background: Conjugated estrogen/bazedoxifene (CE/BZA), the first tissue selective estrogen complex, was developed as an alternative to combination estrogen and progesterone therapy to treat hot flashes and osteoporosis. Preclinical studies found that CE/BZA reduced mammary… read more here.
Keywords: clinical trial; bza placebo; bza; placebo ... See more keywords
Epigenetic and transcriptome responsiveness to ER modulation by tissue selective estrogen complexes in breast epithelial and breast cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0271725
Abstract: Selective estrogen receptor modulators (SERMs), including the SERM/SERD bazedoxifene (BZA), are used to treat postmenopausal osteoporosis and may reduce breast cancer (BCa) risk. One of the most persistent unresolved questions regarding menopausal hormone therapy is… read more here.
Keywords: gene; breast cancer; estrogen; bza ... See more keywords
Effect of conjugated estrogens and bazedoxifene on glucose, energy and lipid metabolism in obese postmenopausal women.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of endocrinology"
DOI: 10.1530/eje-20-0619
Abstract: OBJECTIVE Combining conjugated estrogens (CE) with the selective estrogen receptor modulator bazedoxifene (BZA) is a novel orally-administered menopausal therapy. We investigated the effect of CE/BZA on insulin sensitivity, energy metabolism, and serum metabolome in postmenopausal… read more here.
Keywords: conjugated estrogens; bazedoxifene; bza; effect ... See more keywords
A Novel Dioxythiophene Based Conducting Polymer as Electrode Material for Supercapacitor Application
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DOI: 10.20964/2019.10.35
Abstract: The electrochemical polymerization of the functionalized 3,4-propylenedioxythiophene derivative ProDOT-EtO-BZA 1 bearing an oligoether spacer with aromatic carboxylic group was achieved on platinum (Pt) wire and screen printed carbon electrode (SPCE), respectively. The structure, morphology and… read more here.
Keywords: electrode material; pprodot eto; bza; eto bza ... See more keywords
Bazedoxifene as a Potential Cancer Therapeutic Agent Targeting IL-6/GP130 Signaling
Sign Up to like & getrecommendations! Published in 2024 at "Current Oncology"
DOI: 10.3390/curroncol31100426
Abstract: Targeting the interleukin-6 (IL-6)/glycoprotein 130 (GP130) signaling pathway holds significant promise for cancer therapy given its essential role in the survival and progression of various cancer types. We have identified that bazedoxifene (BZA), a Food… read more here.
Keywords: cancer; gp130 signaling; bza; bazedoxifene potential ... See more keywords