The HDAC6 inhibitor C1A modulates autophagy substrates in diverse cancer cells and induces cell death
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DOI: 10.1038/s41416-018-0232-5
Abstract: BackgroundCytosolic deacetylase histone deacetylase 6 (HDAC6) is involved in the autophagy degradation pathway of malformed proteins, an important survival mechanism in cancer cells. We evaluated modulation of autophagy-related proteins and cell death by the HDAC6-selective inhibitor… read more here.
Keywords: autophagy substrates; c1a; cancer; cell death ... See more keywords
Exclusive Production of Gentamicin C1a from Micromonospora purpurea by Metabolic Engineering
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DOI: 10.3390/antibiotics8040267
Abstract: Gentamicin C1a is an important precursor to the synthesis of etimicin, a potent antibiotic. Wild type Micromonospora purpurea Gb1008 produces gentamicin C1a, besides four other gentamicin C components: C1, C2, C2a, and C2b. While the… read more here.
Keywords: micromonospora purpurea; c1a; gentamicin c1a; c2b ... See more keywords