Reviewing clinical considerations and guideline recommendations of C1 inhibitor prophylaxis for hereditary angioedema
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DOI: 10.1002/clt2.12092
Abstract: Abstract Background Hereditary angioedema (HAE), a rare disease that is characterized by painful and recurring non‐allergic swelling episodes, is caused by the deficiency or dysfunction of C1 inhibitor (C1INH) protein. A comprehensive HAE management plan… read more here.
Keywords: hae; hereditary angioedema; clinical considerations; guideline recommendations ... See more keywords
Knockdown of circulating C1 inhibitor induces neurovascular impairment, glial cell activation, neuroinflammation, and behavioral deficits
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DOI: 10.1002/glia.23611
Abstract: The cross‐talk between blood proteins, immune cells, and brain function involves complex mechanisms. Plasma protein C1 inhibitor (C1INH) is an inhibitor of vascular inflammation that is induced by activation of the kallikrein‐kinin system (KKS) and… read more here.
Keywords: inhibitor; system; c1inh; pathology ... See more keywords
Contradictory to its effects on thrombin, C1-inhibitor reduces plasmin generation in the presence of thrombomodulin
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DOI: 10.1007/s11239-019-01869-y
Abstract: C1-inhibitor (C1INH) was shown to enhance thrombin generation (TG) in the presence of thrombomodulin (TM) by reducing production of activated protein C. Because C1INH is known to inhibit fibrinolytic system proteases, the objective of this… read more here.
Keywords: presence; c1inh; presence thrombomodulin; plasmin generation ... See more keywords
Diagnostic biologique des angioedèmes bradykiniques : les recommandations du CREAK
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DOI: 10.1016/j.lpm.2018.06.015
Abstract: Bradykinin mediated angioedema (BK-AE) can be associated either with C1Inhibitor deficiency (hereditary and acquired forms), either with normal C1Inh (hereditary form and drug induced AE as angiotensin converting enzyme inhibitors…). In case of high clinical… read more here.
Keywords: diagnostic biologique; c1inh; des angioed; biologique des ... See more keywords