Translocation and activation of sphingosine kinase 1 by ceramide‐1‐phosphate
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DOI: 10.1002/jcb.27818
Abstract: Sphingosine kinases (SphKs) and ceramide kinase (CerK) phosphorylate sphingosine to sphingosine‐1‐phosphate (S1P) and ceramide to ceramide‐1‐phosphate (C1P), respectively. S1P and C1P are bioactive lipids that regulate cell fate/function and human health/diseases. The translocation and activity… read more here.
Keywords: sphk1; ceramide; c1p; translocation ... See more keywords
Ceramide-1-phosphate is a regulator of Golgi structure and is co-opted by the obligate intracellular bacterial pathogen Anaplasma phagocytophilum
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DOI: 10.1128/mbio.00299-24
Abstract: ABSTRACT Many intracellular pathogens structurally disrupt the Golgi apparatus as an evolutionarily conserved promicrobial strategy. Yet, the host factors and signaling processes involved are often poorly understood, particularly for Anaplasma phagocytophilum, the agent of human… read more here.
Keywords: golgi morphology; golgi; phagocytophilum; ceramide phosphate ... See more keywords
Decreased Innate Migration of Pro-Inflammatory M1 Macrophages through the Mesothelial Membrane Is Affected by Ceramide Kinase and Ceramide 1-P
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DOI: 10.3390/ijms232415977
Abstract: The retrograde flow of endometrial tissues deposited into the peritoneal cavity occurs in women during menstruation. Classically (M1) or alternatively (M2) activated macrophages partake in the removal of regurgitated menstrual tissue. The failure of macrophage… read more here.
Keywords: ceramide kinase; pro inflammatory; migration; membrane ... See more keywords