Tumor‐shed antigen CA125 blocks complement‐mediated killing via suppression of C1q‐antibody binding
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201847707
Abstract: C1q‐engagement with IgG and IgM type antibodies is the initiating step of classical complement‐mediated immunity. The tumor shed antigen CA125 has been reported to have immunosuppressive effects on host tumor responses as well as commercially… read more here.
Keywords: ca125; antibody; c1q; complement ... See more keywords
Association of C1q gene cluster variants with rheumatoid arthritis: a pilot study
Sign Up to like & getrecommendations! Published in 2022 at "Rheumatology International"
DOI: 10.1007/s00296-022-05089-1
Abstract: Single-nucleotide polymorphisms (SNPs) in C1q gene cluster were previously linked to autoimmunity and SLE, but data are scarce for their association with RA. In the present study, we evaluated associations of five SNPs (rs665691, rs682658,… read more here.
Keywords: study; c1q; gene cluster; association ... See more keywords
Inflammatory and Oxidative Pathways Are New Drug Targets in Multiple Episode Schizophrenia and Leaky Gut, Klebsiella pneumoniae, and C1q Immune Complexes Are Additional Drug Targets in First Episode Schizophrenia.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02343-8
Abstract: Breakdown of paracellular and vascular pathways and activated neuroimmune and oxidative pathways was established in (deficit) schizophrenia. The aim of this study was to delineate (a) the differences in these pathways between stable-phase, first (FES)… read more here.
Keywords: drug targets; schizophrenia; pneumoniae; c1q ... See more keywords
Novel Monoclonal Antibodies Against Mouse C1q: Characterisation and Development of a Quantitative ELISA for Mouse C1q
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Neurobiology"
DOI: 10.1007/s12035-021-02419-5
Abstract: Recent studies have identified roles for complement in synaptic pruning, both physiological during development and pathological in Alzheimer’s disease (AD). These reports suggest that C1q initiates complement activation on synapses and C3 fragments then tag… read more here.
Keywords: c1q levels; novel monoclonal; c1q; mouse c1q ... See more keywords
A novel C1q‐domain‐containing protein from razor clam Sinonovacula constricta mediates G‐bacterial agglutination as a pattern recognition receptor
Sign Up to like & getrecommendations! Published in 2018 at "Developmental and Comparative Immunology"
DOI: 10.1016/j.dci.2017.10.022
Abstract: ABSTRACT Complement component 1q (C1q) with a characteristic C1q globular domain is an important pattern recognition molecule in the classical complement systems and plays a major role in the crosslinking between innate immunity and specific… read more here.
Keywords: pattern recognition; c1q; sinonovacula constricta; scc1qdc ... See more keywords
Clinical and prognostic significance of C1q deposition in IgAN patients-a retrospective study.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106896
Abstract: BACKGROUND/AIM IgA nephropathy (IgAN) is the most prevalent primary glomerular disease worldwide and is responsible for 45-50% of primary glomerular diseases in China. We are essentially dependent on the degree of proteinuria to determine prognosis… read more here.
Keywords: c1q negative; group; c1q; igan patients ... See more keywords
Functional recombinant human complement C1q with different affinity tags.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of immunological methods"
DOI: 10.1016/j.jim.2021.113001
Abstract: Complement C1q is a multifunctional protein able to sense pathogens and immune molecules such as immunoglobulins and pentraxins, and to trigger the classical complement pathway through activation of its two associated proteases, C1r and C1s.… read more here.
Keywords: recombinant human; complement c1q; c1q; complement ... See more keywords
Complement component C1q is produced by isolated articular chondrocytes.
Sign Up to like & getrecommendations! Published in 2019 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2019.09.007
Abstract: OBJECTIVE Inflammation and innate immune responses may contribute to development and progression of Osteoarthritis (OA). Chondrocytes are the sole cell type of the articular cartilage and produce extracellular-matrix molecules. How inflammatory mediators reach chondrocytes is… read more here.
Keywords: c1q; articular chondrocytes; mrna expression; c1qa c1qb ... See more keywords
A robust multiplexed assay to quantify C1-inhibitor, C1q, and C4 proteins for in vitro diagnosis of hereditary angioedema from dried blood spot.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2020.113844
Abstract: Hereditary angioedema (HAE) is a rare genetic disease caused by deficiency or dysfunction of C1 esterase inhibitor (C1-INH). Plasma C1-INH activity and concentrations of C1-INH and complement components 1q and 4 (C1q, C4) are critical… read more here.
Keywords: multiplexed assay; blood spot; c1q; dried blood ... See more keywords
The regulatory role of C1q on Helicobacter pylori-induced inflammatory cytokines secretion in THP-1 cells.
Sign Up to like & getrecommendations! Published in 2019 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2019.04.017
Abstract: C1q, as a LAIR-1 ligand, maintains monocytes quiescence and possess immunosuppressive properties. To understand the roles and molecular mechanisms, C1q mediated inflammation cytokines and several pivotal proteins in THP-1 cells after H. pylori infection were detected.… read more here.
Keywords: p38 mapk; phosphorylated total; c1q; pylori infection ... See more keywords
Recombinant C1q variants modulate macrophage responses but do not activate the classical complement pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular immunology"
DOI: 10.1016/j.molimm.2019.10.008
Abstract: Complement protein C1q plays a dual role in a number of inflammatory diseases such as atherosclerosis. While in later stages classical complement pathway activation by C1q exacerbates disease progression, C1q also plays a beneficial role… read more here.
Keywords: rc1q; complement pathway; classical complement; c1q ... See more keywords