Complement (C1q) Binding De Novo Donor-Specific Antibodies and Cardiac-Allograft Vasculopathy in Pediatric Heart Transplant Recipients
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DOI: 10.1097/tp.0000000000001944
Abstract: Background We hypothesized C1q binding de novo donor-specific antibody (DSA) after heart transplant (HT) is a higher risk for development of coronary artery vasculopathy (CAV) in children. Methods A retrospective analysis of 127 pediatric HT… read more here.
Keywords: c1q binding; heart; binding novo; dsa ... See more keywords
Effects of weak/non‐complement‐binding HLA antibodies on C1q‐binding
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DOI: 10.1111/tan.13062
Abstract: It is unknown under what conditions and to what extent weak/non‐complement (C)‐binding IgG subclasses (IgG2/IgG4) can block C1q‐binding triggered by C‐binding IgG subclasses (IgG1/IgG3). Therefore, we investigated in vitro C1q‐binding induced by IgG subclass mixtures… read more here.
Keywords: c1q binding; weak non; non complement; c1q ... See more keywords
Complement C1q Binding Protein (C1QBP): Physiological Functions, Mutation-Associated Mitochondrial Cardiomyopathy and Current Disease Models
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DOI: 10.3389/fcvm.2022.843853
Abstract: Complement C1q binding protein (C1QBP, p32) is primarily localized in mitochondrial matrix and associated with mitochondrial oxidative phosphorylative function. C1QBP deficiency presents as a mitochondrial disorder involving multiple organ systems. Recently, disease associated C1QBP mutations… read more here.
Keywords: c1q binding; protein c1qbp; binding protein; complement c1q ... See more keywords